Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3768613..3769142 | Replicon | chromosome |
| Accession | NZ_CP089773 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1430 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ68_RS17810 | Protein ID | WP_003417760.1 |
| Coordinates | 3768885..3769142 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ68_RS17805 | Protein ID | WP_003417757.1 |
| Coordinates | 3768613..3768888 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ68_RS17770 (LVJ68_17770) | 3765186..3765875 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ68_RS17775 (LVJ68_17775) | 3766062..3766433 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ68_RS17780 (LVJ68_17780) | 3766331..3766549 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ68_RS17785 (LVJ68_17785) | 3766576..3766836 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ68_RS17790 (LVJ68_17790) | 3766951..3767340 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ68_RS17795 (LVJ68_17795) | 3767354..3767647 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ68_RS17800 (LVJ68_17800) | 3767644..3768489 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ68_RS17805 (LVJ68_17805) | 3768613..3768888 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ68_RS17810 (LVJ68_17810) | 3768885..3769142 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ68_RS17815 (LVJ68_17815) | 3769184..3770374 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LVJ68_RS17820 (LVJ68_17820) | 3770491..3770859 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ68_RS17825 (LVJ68_17825) | 3770856..3771407 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ68_RS17830 (LVJ68_17830) | 3771414..3771995 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ68_RS17835 (LVJ68_17835) | 3771976..3772344 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ68_RS17840 (LVJ68_17840) | 3772322..3772714 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T228777 WP_003417760.1 NZ_CP089773:3768885-3769142 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T228777 NZ_CP124343:3633178-3633396 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT228777 WP_003417757.1 NZ_CP089773:3768613-3768888 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT228777 NZ_CP124343:3632778-3633152 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|