Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3708134..3708808 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ68_RS17600 Protein ID WP_003417282.1
Coordinates 3708134..3708562 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ68_RS17605 Protein ID WP_003417286.1
Coordinates 3708566..3708808 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS17575 (LVJ68_17575) 3703956..3704357 - 402 WP_003417264.1 cytidine deaminase -
LVJ68_RS17580 (LVJ68_17580) 3704594..3704932 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ68_RS17585 (LVJ68_17585) 3704929..3705363 + 435 WP_003913036.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ68_RS17590 (LVJ68_17590) 3705492..3707264 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ68_RS17595 (LVJ68_17595) 3707264..3708055 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ68_RS17600 (LVJ68_17600) 3708134..3708562 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS17605 (LVJ68_17605) 3708566..3708808 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ68_RS17610 (LVJ68_17610) 3708930..3709544 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ68_RS17615 (LVJ68_17615) 3709541..3710206 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ68_RS17620 (LVJ68_17620) 3710207..3710740 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ68_RS17625 (LVJ68_17625) 3710737..3711111 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ68_RS17630 (LVJ68_17630) 3711208..3712344 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228776 WP_003417282.1 NZ_CP089773:c3708562-3708134 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228776 NZ_CP124343:c3604235-3603933 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228776 WP_003417286.1 NZ_CP089773:c3708808-3708566 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228776 NZ_CP124343:c3603897-3603556 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References