228774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3186098..3186785 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag LVJ68_RS15235 Protein ID WP_003414624.1
Coordinates 3186342..3186785 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag LVJ68_RS15230 Protein ID WP_003414620.1
Coordinates 3186098..3186355 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS15210 (LVJ68_15210) 3181418..3182272 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
LVJ68_RS15215 (LVJ68_15215) 3182328..3183491 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LVJ68_RS15220 (LVJ68_15220) 3183508..3184722 - 1215 WP_003899518.1 zinc metalloprotease Rip -
LVJ68_RS15225 (LVJ68_15225) 3184730..3185971 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
LVJ68_RS15230 (LVJ68_15230) 3186098..3186355 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
LVJ68_RS15235 (LVJ68_15235) 3186342..3186785 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS15240 (LVJ68_15240) 3186865..3187527 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
LVJ68_RS15245 (LVJ68_15245) 3187623..3187814 + 192 WP_003414632.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LVJ68_RS15250 (LVJ68_15250) 3188146..3189894 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
LVJ68_RS15255 (LVJ68_15255) 3189990..3190571 + 582 WP_003414644.1 fasciclin domain-containing protein -
LVJ68_RS15260 (LVJ68_15260) 3190671..3190937 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T228774 WP_003414624.1 NZ_CP089773:3186342-3186785 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T228774 NZ_CP124343:2801421-2801528 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT228774 WP_003414620.1 NZ_CP089773:3186098-3186355 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT228774 NZ_CP124343:c2801364-2801309 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References