Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3111754..3112324 | Replicon | chromosome |
| Accession | NZ_CP089773 | ||
| Organism | Mycobacterium tuberculosis strain 01-R1430 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | P71650 |
| Locus tag | LVJ68_RS14850 | Protein ID | WP_003414166.1 |
| Coordinates | 3111754..3112110 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL61 |
| Locus tag | LVJ68_RS14855 | Protein ID | WP_003901465.1 |
| Coordinates | 3112094..3112324 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ68_RS14830 (LVJ68_14835) | 3107206..3108894 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
| LVJ68_RS14835 (LVJ68_14840) | 3108898..3109224 | - | 327 | WP_003414157.1 | hypothetical protein | - |
| LVJ68_RS14840 (LVJ68_14845) | 3109397..3109984 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
| LVJ68_RS14845 (LVJ68_14850) | 3110003..3111652 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
| LVJ68_RS14850 (LVJ68_14855) | 3111754..3112110 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
| LVJ68_RS14855 (LVJ68_14860) | 3112094..3112324 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
| LVJ68_RS14860 (LVJ68_14865) | 3112367..3113410 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
| LVJ68_RS14865 (LVJ68_14870) | 3113409..3113876 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
| LVJ68_RS14870 (LVJ68_14875) | 3113905..3114159 | - | 255 | WP_003917684.1 | hypothetical protein | - |
| LVJ68_RS14875 (LVJ68_14880) | 3114307..3114711 | + | 405 | WP_009938577.1 | hypothetical protein | - |
| LVJ68_RS14880 (LVJ68_14885) | 3114708..3114899 | + | 192 | WP_003414184.1 | hypothetical protein | - |
| LVJ68_RS14885 (LVJ68_14890) | 3115116..3115376 | + | 261 | Protein_2938 | transposase | - |
| LVJ68_RS14890 (LVJ68_14895) | 3116486..3116743 | + | 258 | WP_003899489.1 | hypothetical protein | - |
| LVJ68_RS14895 (LVJ68_14900) | 3116848..3117159 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T228770 WP_003414166.1 NZ_CP089773:c3112110-3111754 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T228770 NZ_CP124343:2012547-2012801 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT228770 WP_003901465.1 NZ_CP089773:c3112324-3112094 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT228770 NZ_CP124343:2012299-2012550 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|