Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2932858..2933572 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ68_RS13800 Protein ID WP_003413460.1
Coordinates 2933132..2933572 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ68_RS13795 Protein ID WP_003413456.1
Coordinates 2932858..2933145 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS13760 (LVJ68_13760) 2928280..2928525 + 246 WP_070892801.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ68_RS13765 (LVJ68_13765) 2928522..2928926 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ68_RS13770 (LVJ68_13770) 2929143..2929763 + 621 WP_003912795.1 DUF4178 domain-containing protein -
LVJ68_RS13775 (LVJ68_13775) 2929774..2930268 + 495 WP_003413444.1 DUF2617 family protein -
LVJ68_RS13780 (LVJ68_13780) 2930265..2930696 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ68_RS13785 (LVJ68_13785) 2930721..2931179 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ68_RS13790 (LVJ68_13790) 2931176..2932747 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LVJ68_RS13795 (LVJ68_13795) 2932858..2933145 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ68_RS13800 (LVJ68_13800) 2933132..2933572 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS13805 (LVJ68_13805) 2933593..2934348 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ68_RS13810 (LVJ68_13810) 2934481..2935077 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ68_RS13815 (LVJ68_13815) 2935085..2935930 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ68_RS13820 (LVJ68_13820) 2935959..2936858 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ68_RS13825 (LVJ68_13825) 2936986..2937660 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T228766 WP_003413460.1 NZ_CP089773:2933132-2933572 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T228766 NZ_CP124343:645572-645886 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT228766 WP_003413456.1 NZ_CP089773:2932858-2933145 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT228766 NZ_CP124343:645883-646299 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References