Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2857057..2857697 | Replicon | chromosome |
Accession | NZ_CP089773 | ||
Organism | Mycobacterium tuberculosis strain 01-R1430 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ08 |
Locus tag | LVJ68_RS13425 | Protein ID | WP_003412970.1 |
Coordinates | 2857057..2857476 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ09 |
Locus tag | LVJ68_RS13430 | Protein ID | WP_003412975.1 |
Coordinates | 2857473..2857697 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ68_RS13395 (LVJ68_13395) | 2852642..2853364 | - | 723 | WP_003412957.1 | DUF1906 domain-containing protein | - |
LVJ68_RS13400 (LVJ68_13400) | 2853881..2854108 | + | 228 | WP_003412960.1 | type II toxin-antitoxin system VapB family antitoxin | - |
LVJ68_RS13405 (LVJ68_13405) | 2854105..2854506 | + | 402 | WP_003412963.1 | PIN domain-containing protein | - |
LVJ68_RS13410 (LVJ68_13410) | 2854541..2855461 | - | 921 | WP_003412965.1 | restriction endonuclease | - |
LVJ68_RS13415 (LVJ68_13415) | 2855802..2856047 | - | 246 | WP_071854223.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
LVJ68_RS13420 (LVJ68_13420) | 2856106..2857056 | + | 951 | WP_003911916.1 | ERCC4 domain-containing protein | - |
LVJ68_RS13425 (LVJ68_13425) | 2857057..2857476 | - | 420 | WP_003412970.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LVJ68_RS13430 (LVJ68_13430) | 2857473..2857697 | - | 225 | WP_003412975.1 | antitoxin VapB39 | Antitoxin |
LVJ68_RS13435 (LVJ68_13435) | 2857728..2860571 | - | 2844 | WP_003899363.1 | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | - |
LVJ68_RS13440 (LVJ68_13440) | 2860643..2861044 | - | 402 | WP_003412981.1 | hypothetical protein | - |
LVJ68_RS13445 (LVJ68_13445) | 2861044..2861514 | - | 471 | WP_003899364.1 | transcription antitermination factor NusB | - |
LVJ68_RS13450 (LVJ68_13450) | 2861517..2862080 | - | 564 | WP_003412989.1 | elongation factor P | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14732.70 Da Isoelectric Point: 6.7519
>T228762 WP_003412970.1 NZ_CP089773:c2857476-2857057 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL
Download Length: 420 bp
>T228762 NZ_CP124343:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 7993.94 Da Isoelectric Point: 4.0057
>AT228762 WP_003412975.1 NZ_CP089773:c2857697-2857473 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV
Download Length: 225 bp
>AT228762 NZ_CP124343:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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