Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2857057..2857697 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag LVJ68_RS13425 Protein ID WP_003412970.1
Coordinates 2857057..2857476 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag LVJ68_RS13430 Protein ID WP_003412975.1
Coordinates 2857473..2857697 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS13395 (LVJ68_13395) 2852642..2853364 - 723 WP_003412957.1 DUF1906 domain-containing protein -
LVJ68_RS13400 (LVJ68_13400) 2853881..2854108 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
LVJ68_RS13405 (LVJ68_13405) 2854105..2854506 + 402 WP_003412963.1 PIN domain-containing protein -
LVJ68_RS13410 (LVJ68_13410) 2854541..2855461 - 921 WP_003412965.1 restriction endonuclease -
LVJ68_RS13415 (LVJ68_13415) 2855802..2856047 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ68_RS13420 (LVJ68_13420) 2856106..2857056 + 951 WP_003911916.1 ERCC4 domain-containing protein -
LVJ68_RS13425 (LVJ68_13425) 2857057..2857476 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS13430 (LVJ68_13430) 2857473..2857697 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
LVJ68_RS13435 (LVJ68_13435) 2857728..2860571 - 2844 WP_003899363.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
LVJ68_RS13440 (LVJ68_13440) 2860643..2861044 - 402 WP_003412981.1 hypothetical protein -
LVJ68_RS13445 (LVJ68_13445) 2861044..2861514 - 471 WP_003899364.1 transcription antitermination factor NusB -
LVJ68_RS13450 (LVJ68_13450) 2861517..2862080 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T228762 WP_003412970.1 NZ_CP089773:c2857476-2857057 [Mycobacterium tuberculosis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

>T228762 NZ_CP124343:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT228762 WP_003412975.1 NZ_CP089773:c2857697-2857473 [Mycobacterium tuberculosis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp

>AT228762 NZ_CP124343:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References