Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2405406..2405935 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LVJ68_RS11300 Protein ID WP_003411124.1
Coordinates 2405406..2405723 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LVJ68_RS11305 Protein ID WP_003411127.1
Coordinates 2405720..2405935 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS11270 (LVJ68_11280) 2400543..2401619 + 1077 WP_003411110.1 hypothetical protein -
LVJ68_RS11275 (LVJ68_11285) 2401616..2401897 + 282 WP_003411112.1 DUF5703 family protein -
LVJ68_RS11280 (LVJ68_11290) 2401933..2403006 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LVJ68_RS11285 (LVJ68_11295) 2403011..2403541 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LVJ68_RS11290 (LVJ68_11300) 2403589..2404935 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LVJ68_RS11300 (LVJ68_11310) 2405406..2405723 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ68_RS11305 (LVJ68_11315) 2405720..2405935 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LVJ68_RS11310 (LVJ68_11320) 2406190..2407248 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LVJ68_RS11315 (LVJ68_11325) 2407378..2407734 - 357 WP_003411130.1 hypothetical protein -
LVJ68_RS11320 (LVJ68_11330) 2407829..2408611 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LVJ68_RS11325 (LVJ68_11335) 2408879..2409169 - 291 WP_003900476.1 YggT family protein -
LVJ68_RS11330 (LVJ68_11340) 2409331..2409987 - 657 WP_003411133.1 cell division protein SepF -
LVJ68_RS11335 (LVJ68_11345) 2410053..2410829 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T228760 WP_003411124.1 NZ_CP089773:c2405723-2405406 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T228760 NZ_CP124341:c4520134-4519961 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT228760 WP_003411127.1 NZ_CP089773:c2405935-2405720 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT228760 NZ_CP124341:c4520458-4520162 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References