Detailed information of TA system TA022876

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3116664..3117324
• Replicon: chromosome
• Accession: NC_010694
• Organism: Erwinia tasmaniensis Et1/99

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ETA_RS15160
• Protein ID: WP_042959116.1
• Coordinates: 3116664..3117077 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: B2VFS2
• Locus tag: ETA_RS15165
• Protein ID: WP_012442494.1
• Coordinates: 3117058..3117324 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETA_RS15140	3113024..3113725	-	702	WP_012442489.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ETA_RS15145	3113771..3114664	-	894	WP_012442490.1	site-specific tyrosine recombinase XerD	-
ETA_RS15150	3114883..3115836	+	954	WP_012442491.1	DMT family transporter	-
ETA_RS15155	3116020..3116538	+	519	WP_012442492.1	flavodoxin FldB	-
ETA_RS15160	3116664..3117077	-	414	WP_042959116.1	membrane protein	Toxin
ETA_RS15165	3117058..3117324	-	267	WP_012442494.1	FAD assembly factor SdhE	Antitoxin
ETA_RS15170	3117549..3118535	+	987	WP_012442495.1	tRNA-modifying protein YgfZ	-
ETA_RS15175	3118536..3119195	-	660	WP_012442496.1	hemolysin III family protein	-
ETA_RS15180	3119409..3120017	+	609	WP_012442497.1	HD domain-containing protein	-
ETA_RS15185	3120106..3120849	-	744	WP_012442498.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-129)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16124.18 Da
• Isoelectric Point: 12.2329

>T22876 WP_042959116.1 NC_010694:c3117077-3116664 [Erwinia tasmaniensis Et1/99]
VVLWQSELRKSTLARRSSLLLHGMVMLALLLASWPVSATPVRMLLLALVLLDCLRSLRRIRRRQGNIALLGGRALRWRQR
EWRILSRPWLTRQAILLSLRDAKGERERLWLFADGMENSSWRCLRMQLLIDREADNE

Nucleotide

• Length: 414 bp

>T22876 NC_010694:c3117077-3116664 [Erwinia tasmaniensis Et1/99]
GTGGTCCTGTGGCAATCTGAGCTACGGAAGTCAACGCTGGCGCGGCGGTCTTCGCTGCTGCTGCATGGTATGGTCATGCT
GGCGCTGCTGCTTGCCTCATGGCCTGTCAGCGCAACCCCCGTGCGGATGCTGCTACTGGCTTTAGTGCTGCTGGATTGCC
TTCGCAGTCTGCGGCGTATCCGCCGCCGCCAGGGGAACATCGCCCTGCTGGGCGGACGTGCGCTACGCTGGCGTCAGCGC
GAGTGGCGCATCCTTTCCCGCCCGTGGCTGACCCGACAGGCGATCCTGCTGTCACTGCGTGATGCCAAAGGGGAGCGTGA
ACGGCTGTGGCTGTTCGCCGACGGTATGGAAAACAGCAGCTGGCGTTGCCTGCGCATGCAGCTGCTGATCGACAGGGAAG
CAGACAATGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.03 Da
• Isoelectric Point: 5.7035

>AT22876 WP_012442494.1 NC_010694:c3117324-3117058 [Erwinia tasmaniensis Et1/99]
MDITNKSRIHWACRRGMRELDISIMPFFEYEFDSLNDGDKRLFVRLLESDDPDLFNWLMNHGEPADAELKRMVLLIQQRN
KQRGPVAI

Nucleotide

• Length: 267 bp

>AT22876 NC_010694:c3117324-3117058 [Erwinia tasmaniensis Et1/99]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTGGATATCTCTATCATGCCGTT
TTTTGAGTACGAATTTGACTCGCTGAACGACGGCGACAAGCGTCTGTTCGTCCGCCTGCTGGAGAGCGACGATCCCGACC
TGTTCAACTGGCTGATGAATCACGGAGAGCCGGCAGATGCAGAGCTGAAAAGGATGGTATTGCTGATCCAGCAGAGAAAC
AAACAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: B2VFS2