Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 2255975..2256601 | Replicon | chromosome |
Accession | NZ_CP089773 | ||
Organism | Mycobacterium tuberculosis strain 01-R1430 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P64926 |
Locus tag | LVJ68_RS10600 | Protein ID | WP_003410075.1 |
Coordinates | 2256203..2256601 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A806JLL8 |
Locus tag | LVJ68_RS10595 | Protein ID | WP_003911750.1 |
Coordinates | 2255975..2256202 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ68_RS10585 (LVJ68_10595) | 2254014..2254358 | - | 345 | WP_003410065.1 | ferredoxin family protein | - |
LVJ68_RS10590 (LVJ68_10600) | 2254547..2255716 | - | 1170 | WP_003899126.1 | ATP-binding protein | - |
LVJ68_RS10595 (LVJ68_10605) | 2255975..2256202 | + | 228 | WP_003911750.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LVJ68_RS10600 (LVJ68_10610) | 2256203..2256601 | + | 399 | WP_003410075.1 | PIN domain nuclease | Toxin |
LVJ68_RS10605 (LVJ68_10615) | 2256784..2257215 | - | 432 | WP_003410078.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
LVJ68_RS10610 (LVJ68_10620) | 2257316..2257750 | + | 435 | WP_003914358.1 | DUF1398 domain-containing protein | - |
LVJ68_RS10615 (LVJ68_10625) | 2258187..2258366 | - | 180 | Protein_2098 | hypothetical protein | - |
LVJ68_RS10620 (LVJ68_10630) | 2258454..2259074 | + | 621 | WP_003410086.1 | IS110 family transposase | - |
LVJ68_RS10625 (LVJ68_10635) | 2259028..2259618 | + | 591 | WP_003899131.1 | IS110 family transposase | - |
LVJ68_RS10630 (LVJ68_10640) | 2259746..2261002 | - | 1257 | WP_003410095.1 | HNH endonuclease signature motif containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14731.02 Da Isoelectric Point: 6.7067
>T228756 WP_003410075.1 NZ_CP089773:2256203-2256601 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF
Download Length: 399 bp
>T228756 NZ_CP124341:c4016079-4015765 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8346.16 Da Isoelectric Point: 4.1621
>AT228756 WP_003911750.1 NZ_CP089773:2255975-2256202 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES
Download Length: 228 bp
>AT228756 NZ_CP124341:c4016315-4016082 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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