Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2230669..2231567 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LVJ68_RS10475 Protein ID WP_003410001.1
Coordinates 2230669..2231229 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LVJ68_RS10480 Protein ID WP_003410003.1
Coordinates 2231226..2231567 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS10445 (LVJ68_10455) 2225838..2226491 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ68_RS10450 (LVJ68_10460) 2226606..2226836 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ68_RS10455 (LVJ68_10465) 2226921..2227832 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ68_RS10460 (LVJ68_10470) 2227941..2228540 + 600 WP_003409989.1 L-lysine exporter -
LVJ68_RS10465 (LVJ68_10475) 2228956..2229384 + 429 WP_003409992.1 cellulose-binding protein -
LVJ68_RS10470 (LVJ68_10480) 2229610..2230149 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LVJ68_RS10475 (LVJ68_10485) 2230669..2231229 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LVJ68_RS10480 (LVJ68_10490) 2231226..2231567 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LVJ68_RS10485 (LVJ68_10495) 2231653..2231910 + 258 WP_003410006.1 hypothetical protein -
LVJ68_RS10490 (LVJ68_10500) 2231811..2232146 - 336 WP_003410009.1 dehydrogenase -
LVJ68_RS10495 (LVJ68_10505) 2232235..2232579 - 345 WP_003912702.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LVJ68_RS10500 (LVJ68_10510) 2232573..2232821 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LVJ68_RS10505 (LVJ68_10515) 2232921..2235236 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LVJ68_RS10510 (LVJ68_10520) 2235233..2235505 - 273 WP_003410017.1 DUF1490 family protein -
LVJ68_RS10515 (LVJ68_10525) 2235558..2235914 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T228754 WP_003410001.1 NZ_CP089773:c2231229-2230669 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T228754 NZ_CP124341:3604004-3604222 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT228754 WP_003410003.1 NZ_CP089773:c2231567-2231226 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT228754 NZ_CP124341:3603604-3603978 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References