Detailed information of TA system TA022875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2793272..2793900
• Replicon: chromosome
• Accession: NC_010694
• Organism: Erwinia tasmaniensis Et1/99

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: ETA_RS13620
• Protein ID: WP_012442201.1
• Coordinates: 2793682..2793900 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: B2VHW3
• Locus tag: ETA_RS13615
• Protein ID: WP_012442200.1
• Coordinates: 2793272..2793652 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETA_RS13585	2789416..2789676	+	261	WP_012442194.1	type B 50S ribosomal protein L31	-
ETA_RS13590	2789686..2789829	+	144	WP_012442195.1	type B 50S ribosomal protein L36	-
ETA_RS13595	2789934..2790812	-	879	WP_012442196.1	metal ABC transporter substrate-binding protein	-
ETA_RS13600	2790809..2791678	-	870	WP_012442197.1	metal ABC transporter permease	-
ETA_RS13605	2791675..2792364	-	690	WP_157861809.1	ATP-binding cassette domain-containing protein	-
ETA_RS13610	2792775..2793128	+	354	WP_012442199.1	hypothetical protein	-
ETA_RS13615	2793272..2793652	+	381	WP_012442200.1	Hha toxicity modulator TomB	Antitoxin
ETA_RS13620	2793682..2793900	+	219	WP_012442201.1	hemolysin expression modulator Hha	Toxin
ETA_RS13625	2794198..2794512	+	315	WP_012442202.1	MGMT family protein	-
ETA_RS13630	2794538..2795095	-	558	WP_012442203.1	YbaY family lipoprotein	-
ETA_RS13635	2795319..2796179	+	861	WP_012442204.1	acyl-CoA thioesterase II	-
ETA_RS13640	2796254..2797555	-	1302	WP_012442205.1	ammonium transporter AmtB	-
ETA_RS13645	2797569..2797907	-	339	WP_012442206.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8641.09 Da
• Isoelectric Point: 8.9007

>T22875 WP_012442201.1 NC_010694:2793682-2793900 [Erwinia tasmaniensis Et1/99]
MTEKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Nucleotide

• Length: 219 bp

>T22875 NC_010694:2793682-2793900 [Erwinia tasmaniensis Et1/99]
ATGACTGAAAAACTTCTCACGAAAACTGATTATCTAATGCGCCTCAGACGTTGTCGTTCAATCGACACGCTGGAGCGCGT
GATTGAAAAGAACAAGTACGAATTATCTGATGATGAACTCGCTGTATTTTATTCGGCTGCAGATCACCGCCTTGCCGAAC
TGACTATGAATAAACTGTACGATAAAGTCCCAGTCGCCGTGTGGAAGTTTGTCCGTTAG

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14724.51 Da
• Isoelectric Point: 4.5684

>AT22875 WP_012442200.1 NC_010694:2793272-2793652 [Erwinia tasmaniensis Et1/99]
MDEYSPRRHDIAQLKFLCENLYDEGLATLGDSHHGWVNDPTSTFNLQLNELIEHIAAFTMNYKIKHVEDADLISQIDEYM
DDTFMLFSNYGINIQDLQRWQKSAKLLFNIFAKECVMSQNQASHSF

Nucleotide

• Length: 381 bp

>AT22875 NC_010694:2793272-2793652 [Erwinia tasmaniensis Et1/99]
ATGGACGAATACTCACCGAGAAGGCATGATATTGCGCAACTGAAATTCTTATGTGAAAACCTCTATGACGAAGGTTTGGC
TACGCTGGGCGACAGCCACCACGGCTGGGTTAATGACCCGACATCTACGTTCAACCTACAGCTTAATGAACTGATAGAGC
ATATTGCAGCCTTCACAATGAATTACAAAATAAAGCACGTCGAAGACGCCGATCTGATTAGTCAGATTGATGAGTACATG
GACGACACTTTTATGCTTTTCAGCAATTACGGTATTAACATTCAGGACTTACAACGCTGGCAAAAATCAGCGAAACTTTT
ATTTAACATCTTTGCTAAAGAATGCGTAATGAGCCAAAATCAGGCAAGCCATTCATTTTAG

Structures

Antitoxin

• AlphaFold DB: B2VHW3