228749

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1976894..1977354 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag LVJ68_RS09255 Protein ID WP_003898996.1
Coordinates 1977106..1977354 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LVJ68_RS09250 Protein ID WP_003408528.1
Coordinates 1976894..1977106 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS09235 (LVJ68_09240) 1973372..1974559 - 1188 WP_003898992.1 nitrate transporter NarK -
LVJ68_RS09240 (LVJ68_09245) 1974846..1975130 + 285 WP_003408522.1 DUF1876 domain-containing protein -
LVJ68_RS09245 (LVJ68_09250) 1975144..1976826 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
LVJ68_RS09250 (LVJ68_09255) 1976894..1977106 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ68_RS09255 (LVJ68_09260) 1977106..1977354 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS09260 (LVJ68_09265) 1977362..1978099 + 738 WP_003898997.1 hypothetical protein -
LVJ68_RS09265 (LVJ68_09270) 1978193..1979893 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LVJ68_RS09270 (LVJ68_09275) 1980178..1980579 - 402 WP_003408538.1 hypothetical protein -
LVJ68_RS09275 (LVJ68_09280) 1980569..1981180 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T228749 WP_003898996.1 NZ_CP089773:1977106-1977354 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T228749 NZ_CP124341:2239988-2240090 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT228749 WP_003408528.1 NZ_CP089773:1976894-1977106 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT228749 NZ_CP124341:c2240128-2239860 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References