228748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1956276..1956889 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ68_RS09145 Protein ID WP_003408465.1
Coordinates 1956276..1956665 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ68_RS09150 Protein ID WP_003408469.1
Coordinates 1956662..1956889 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS09110 (LVJ68_09115) 1951905..1952819 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ68_RS09115 (LVJ68_09120) 1952822..1953652 + 831 WP_003408448.1 cyclase family protein -
LVJ68_RS09120 (LVJ68_09125) 1953652..1954002 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ68_RS09125 (LVJ68_09130) 1954055..1954873 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ68_RS09130 (LVJ68_09135) 1954887..1955666 + 780 WP_070892774.1 IclR family transcriptional regulator -
LVJ68_RS09140 (LVJ68_09145) 1956097..1956228 + 132 Protein_1803 IS3 family transposase -
LVJ68_RS09145 (LVJ68_09150) 1956276..1956665 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS09150 (LVJ68_09155) 1956662..1956889 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ68_RS09155 (LVJ68_09160) 1957107..1958591 + 1485 WP_003408473.1 biotin carboxylase -
LVJ68_RS09160 (LVJ68_09165) 1958588..1959835 + 1248 WP_003408476.1 serine hydrolase -
LVJ68_RS09165 (LVJ68_09170) 1959878..1960297 - 420 WP_003408483.1 hypothetical protein -
LVJ68_RS09170 (LVJ68_09175) 1960287..1960997 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T228748 WP_003408465.1 NZ_CP089773:c1956665-1956276 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T228748 NZ_CP124341:c1996912-1996538 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT228748 WP_003408469.1 NZ_CP089773:c1956889-1956662 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT228748 NZ_CP124341:c1997369-1997001 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References