Detailed information of TA system TA022873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 436756..437303
• Replicon: chromosome
• Accession: NC_010694
• Organism: Erwinia tasmaniensis Et1/99

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ETA_RS02995
• Protein ID: WP_042958568.1
• Coordinates: 436756..437031 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B2VGM3
• Locus tag: ETA_RS03000
• Protein ID: WP_012440134.1
• Coordinates: 437031..437303 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETA_RS02975	431801..432256	-	456	WP_012440130.1	DNA polymerase III subunit chi	-
ETA_RS02980	432396..433907	-	1512	WP_012440131.1	leucyl aminopeptidase	-
ETA_RS02985	434161..435261	+	1101	WP_012440132.1	LPS export ABC transporter permease LptF	-
ETA_RS02990	435261..436337	+	1077	WP_012440133.1	LPS export ABC transporter permease LptG	-
ETA_RS02995	436756..437031	-	276	WP_042958568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ETA_RS03000	437031..437303	-	273	WP_012440134.1	ribbon-helix-helix domain-containing protein	Antitoxin
ETA_RS03005	437741..439018	-	1278	WP_012440135.1	DUF445 family protein	-
ETA_RS03010	439020..440519	-	1500	WP_012440136.1	DUF853 domain-containing protein	-
ETA_RS03015	440687..441196	-	510	WP_042959239.1	DUF2501 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10795.32 Da
• Isoelectric Point: 8.5237

>T22873 WP_042958568.1 NC_010694:c437031-436756 [Erwinia tasmaniensis Et1/99]
MEFKWTSKALSDISRLYEFLASVNQPAAARTVQQLTTAPTTLLSNPRIGERLEEFAPRDVRRIHVGHYEMRYEIVESTIY
MLRLWHTREDR

Nucleotide

• Length: 276 bp

>T22873 NC_010694:c437031-436756 [Erwinia tasmaniensis Et1/99]
ATGGAATTTAAGTGGACAAGCAAGGCGCTTTCCGACATTAGCCGACTATACGAGTTTCTGGCCTCGGTGAATCAACCTGC
CGCCGCAAGAACAGTGCAGCAACTCACCACCGCACCTACCACGCTGCTGTCCAACCCGCGCATTGGTGAGCGACTCGAAG
AGTTTGCCCCCAGAGATGTACGCAGGATCCATGTCGGCCATTACGAGATGCGTTATGAGATAGTCGAATCGACTATCTAC
ATGCTGCGCCTGTGGCACACCCGTGAGGACAGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10150.44 Da
• Isoelectric Point: 5.1358

>AT22873 WP_012440134.1 NC_010694:c437303-437031 [Erwinia tasmaniensis Et1/99]
MTTSAKTRSVTAHVPVQLAEKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALDDVDAGRVIDHQAVQAWAESL
STDTPLPVPR

Nucleotide

• Length: 273 bp

>AT22873 NC_010694:c437303-437031 [Erwinia tasmaniensis Et1/99]
ATGACAACCTCCGCAAAAACCCGATCCGTCACAGCTCACGTTCCGGTGCAACTGGCGGAAAAAGTCGATTTGATGGCTGA
GCGTCTGGAGCGATCTAAGAACTGGATCGTCAAGCAAGCTCTCTCTGCCTGGATAGACCAGGAAGAAGAGCGTAGTCGCC
TGACCCGTGAGGCCCTGGATGATGTTGACGCAGGACGCGTTATTGACCACCAAGCCGTCCAGGCCTGGGCTGAGAGTCTT
AGCACCGACACTCCGTTGCCCGTGCCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: B2VGM3