Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707765..708408 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ68_RS03210 Protein ID WP_003403187.1
Coordinates 708007..708408 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ68_RS03205 Protein ID WP_003403184.1
Coordinates 707765..708010 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS03170 (LVJ68_03165) 703165..703575 - 411 WP_070892737.1 HAMP domain-containing protein -
LVJ68_RS03175 (LVJ68_03170) 703559..704254 - 696 WP_206647908.1 response regulator transcription factor -
LVJ68_RS03180 (LVJ68_03175) 704377..704688 + 312 WP_003403164.1 hypothetical protein -
LVJ68_RS03185 (LVJ68_03180) 704760..705710 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ68_RS03190 (LVJ68_03185) 705951..706535 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ68_RS03195 (LVJ68_03190) 706537..707247 + 711 Protein_633 IS607 family element RNA-guided endonuclease TnpB -
LVJ68_RS03200 (LVJ68_03195) 707250..707720 + 471 WP_003898523.1 hypothetical protein -
LVJ68_RS03205 (LVJ68_03200) 707765..708010 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ68_RS03210 (LVJ68_03205) 708007..708408 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ68_RS03215 (LVJ68_03210) 708399..708578 + 180 Protein_637 hypothetical protein -
LVJ68_RS03220 (LVJ68_03215) 708996..709193 - 198 WP_003403191.1 hypothetical protein -
LVJ68_RS03225 (LVJ68_03220) 709273..710430 - 1158 WP_003898524.1 hypothetical protein -
LVJ68_RS03230 (LVJ68_03225) 710482..710703 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ68_RS03235 (LVJ68_03230) 710845..711450 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228728 WP_003403187.1 NZ_CP089773:708007-708408 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228728 NZ_CP124339:2801167-2801274 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228728 WP_003403184.1 NZ_CP089773:707765-708010 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228728 NZ_CP124339:c2801110-2801055 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References