228722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 368302..368945 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ68_RS01605 Protein ID WP_003401566.1
Coordinates 368520..368945 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ68_RS01600 Protein ID WP_003401563.1
Coordinates 368302..368523 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS01575 (LVJ68_01575) 363421..364224 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ68_RS01580 (LVJ68_01580) 364234..365631 - 1398 WP_003401544.1 sulfatase -
LVJ68_RS01585 (LVJ68_01585) 365810..367585 + 1776 WP_010886074.1 PE family protein -
LVJ68_RS01590 (LVJ68_01590) 367728..367955 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ68_RS01595 (LVJ68_01595) 367952..368254 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ68_RS01600 (LVJ68_01600) 368302..368523 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ68_RS01605 (LVJ68_01605) 368520..368945 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ68_RS01610 (LVJ68_01610) 369081..369713 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ68_RS01615 (LVJ68_01615) 369710..370618 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ68_RS01620 (LVJ68_01620) 370626..371216 - 591 WP_229298012.1 hypothetical protein -
LVJ68_RS01625 (LVJ68_01625) 371209..371259 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228722 WP_003401566.1 NZ_CP089773:368520-368945 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228722 NZ_CP124339:977678-978085 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228722 WP_003401563.1 NZ_CP089773:368302-368523 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228722 NZ_CP124339:977431-977697 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References