Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3791035..3791702 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag LVJ67_RS17885 Protein ID WP_003417916.1
Coordinates 3791035..3791427 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag LVJ67_RS17890 Protein ID WP_003912214.1
Coordinates 3791427..3791702 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS17860 3786256..3787866 - 1611 WP_003417910.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
LVJ67_RS17865 3787811..3788092 - 282 WP_003914149.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
LVJ67_RS17870 (LVJ67_17870) 3788089..3788793 - 705 Protein_3530 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LVJ67_RS17875 (LVJ67_17875) 3788795..3789229 - 435 Protein_3531 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LVJ67_RS17880 (LVJ67_17880) 3789229..3790281 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
LVJ67_RS17885 (LVJ67_17885) 3791035..3791427 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS17890 (LVJ67_17890) 3791427..3791702 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ67_RS17895 (LVJ67_17895) 3791884..3793255 + 1372 Protein_3535 ISNCY family transposase -
LVJ67_RS17900 (LVJ67_17900) 3793445..3795640 + 2196 WP_010886168.1 PE family protein -
LVJ67_RS17905 (LVJ67_17905) 3795711..3796583 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3792578..3793255 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T228717 WP_003417916.1 NZ_CP089772:c3791427-3791035 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T228717 NZ_CP124339:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT228717 WP_003912214.1 NZ_CP089772:c3791702-3791427 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT228717 NZ_CP124339:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References