Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3763763..3764292 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag LVJ67_RS17750 Protein ID WP_003417760.1
Coordinates 3764035..3764292 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag LVJ67_RS17745 Protein ID WP_003417757.1
Coordinates 3763763..3764038 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS17710 (LVJ67_17710) 3760336..3761025 - 690 WP_003917774.1 BBE domain-containing protein -
LVJ67_RS17715 (LVJ67_17715) 3761212..3761583 - 372 WP_003417739.1 FAD-binding protein -
LVJ67_RS17720 (LVJ67_17720) 3761481..3761699 - 219 WP_157132559.1 hypothetical protein -
LVJ67_RS17725 (LVJ67_17725) 3761726..3761986 - 261 WP_003417741.1 hypothetical protein -
LVJ67_RS17730 (LVJ67_17730) 3762101..3762490 + 390 WP_003417745.1 DUF732 domain-containing protein -
LVJ67_RS17735 (LVJ67_17735) 3762504..3762797 - 294 WP_003417749.1 DUF3017 domain-containing protein -
LVJ67_RS17740 (LVJ67_17740) 3762794..3763639 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
LVJ67_RS17745 (LVJ67_17745) 3763763..3764038 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
LVJ67_RS17750 (LVJ67_17750) 3764035..3764292 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
LVJ67_RS17755 (LVJ67_17755) 3764334..3765524 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
LVJ67_RS17760 (LVJ67_17760) 3765641..3766009 + 369 WP_003417765.1 FHA domain-containing protein -
LVJ67_RS17765 (LVJ67_17765) 3766006..3766557 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
LVJ67_RS17770 (LVJ67_17770) 3766564..3767145 - 582 WP_003417769.1 ATP/GTP-binding protein -
LVJ67_RS17775 (LVJ67_17775) 3767126..3767494 - 369 WP_003417772.1 DUF742 domain-containing protein -
LVJ67_RS17780 (LVJ67_17780) 3767472..3767864 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T228716 WP_003417760.1 NZ_CP089772:3764035-3764292 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T228716 NZ_CP124339:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT228716 WP_003417757.1 NZ_CP089772:3763763-3764038 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT228716 NZ_CP124339:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References