Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3708930..3709604 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LVJ67_RS17560 Protein ID WP_003417282.1
Coordinates 3708930..3709358 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LVJ67_RS17565 Protein ID WP_003417286.1
Coordinates 3709362..3709604 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS17535 (LVJ67_17535) 3704752..3705153 - 402 WP_003417264.1 cytidine deaminase -
LVJ67_RS17540 (LVJ67_17540) 3705390..3705728 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LVJ67_RS17545 (LVJ67_17545) 3705725..3706159 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LVJ67_RS17550 (LVJ67_17550) 3706288..3708060 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LVJ67_RS17555 (LVJ67_17555) 3708060..3708851 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LVJ67_RS17560 (LVJ67_17560) 3708930..3709358 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS17565 (LVJ67_17565) 3709362..3709604 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LVJ67_RS17570 (LVJ67_17570) 3709726..3710340 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LVJ67_RS17575 (LVJ67_17575) 3710337..3711002 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LVJ67_RS17580 (LVJ67_17580) 3711003..3711536 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LVJ67_RS17585 (LVJ67_17585) 3711533..3711907 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
LVJ67_RS17595 (LVJ67_17595) 3713362..3714498 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T228715 WP_003417282.1 NZ_CP089772:c3709358-3708930 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T228715 NZ_CP124338:c133843-133538 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT228715 WP_003417286.1 NZ_CP089772:c3709604-3709362 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT228715 NZ_CP124338:c134063-133845 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References