Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3070372..3071051 | Replicon | chromosome |
| Accession | NZ_CP089772 | ||
| Organism | Mycobacterium tuberculosis strain I0003165-3 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | LVJ67_RS14560 | Protein ID | WP_003414059.1 |
| Coordinates | 3070372..3070788 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | LVJ67_RS14565 | Protein ID | WP_003414061.1 |
| Coordinates | 3070785..3071051 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ67_RS14540 (LVJ67_14535) | 3066424..3067326 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| LVJ67_RS14545 (LVJ67_14540) | 3067395..3068147 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| LVJ67_RS14550 (LVJ67_14550) | 3068391..3068666 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| LVJ67_RS14555 (LVJ67_14555) | 3068663..3070285 | - | 1623 | WP_003906897.1 | class I SAM-dependent DNA methyltransferase | - |
| LVJ67_RS14560 (LVJ67_14560) | 3070372..3070788 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| LVJ67_RS14565 (LVJ67_14565) | 3070785..3071051 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LVJ67_RS14570 (LVJ67_14570) | 3071077..3071472 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ67_RS14575 (LVJ67_14575) | 3071469..3071738 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LVJ67_RS14580 (LVJ67_14580) | 3071748..3072842 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| LVJ67_RS14585 (LVJ67_14585) | 3072839..3073258 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| LVJ67_RS14590 (LVJ67_14590) | 3073257..3073331 | + | 75 | Protein_2879 | hypothetical protein | - |
| LVJ67_RS14595 (LVJ67_14595) | 3073332..3073811 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| LVJ67_RS14600 (LVJ67_14600) | 3073882..3074682 | - | 801 | WP_009939104.1 | thymidylate synthase | - |
| LVJ67_RS14605 (LVJ67_14605) | 3074838..3075575 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T228708 WP_003414059.1 NZ_CP089772:c3070788-3070372 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T228708 NZ_CP124337:3615163-3615381 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT228708 WP_003414061.1 NZ_CP089772:c3071051-3070785 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT228708 NZ_CP124337:3614763-3615137 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|