Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4248946..4249535 Replicon chromosome
Accession NC_010681
Organism Burkholderia phytofirmans PsJN

Toxin (Protein)


Gene name hicA Uniprot ID B2T7A5
Locus tag BPHYT_RS18915 Protein ID WP_012434712.1
Coordinates 4248946..4249128 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2T7A6
Locus tag BPHYT_RS18920 Protein ID WP_012434713.1
Coordinates 4249125..4249535 (+) Length 137 a.a.

Genomic Context


BPHYT_RS18900BPHYT_RS18905BPHYT_RS18910BPHYT_RS18915BPHYT_RS18920BPHYT_RS18885BPHYT_RS18890BPHYT_RS18895BPHYT_RS18925BPHYT_RS18930BPHYT_RS18935
Location: 4246027..4247541 (1515 bp)
Type: Others
Protein ID: WP_012434709.1
Location: 4247743..4248096 (354 bp)
Type: Others
Protein ID: WP_012434710.1
Location: 4248191..4248637 (447 bp)
Type: Others
Protein ID: WP_012434711.1
Location: 4248946..4249128 (183 bp)
Type: Toxin
Protein ID: WP_012434712.1
Location: 4249125..4249535 (411 bp)
Type: Antitoxin
Protein ID: WP_012434713.1
Location: 4244064..4244786 (723 bp)
Type: Others
Protein ID: WP_012434706.1
Location: 4244797..4245222 (426 bp)
Type: Others
Protein ID: WP_012434707.1
Location: 4245315..4245809 (495 bp)
Type: Others
Protein ID: WP_012434708.1
Location: 4249596..4250330 (735 bp)
Type: Others
Protein ID: WP_012434714.1
Location: 4250359..4251228 (870 bp)
Type: Others
Protein ID: WP_041758634.1
Location: 4251221..4253146 (1926 bp)
Type: Others
Protein ID: WP_041758636.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BPHYT_RS188854244064..4244786-723WP_012434706.1flagellar hook assembly protein FlgD-
BPHYT_RS188904244797..4245222-426WP_012434707.1flagellar basal body rod protein FlgC-
BPHYT_RS188954245315..4245809-495WP_012434708.1flagellar basal body rod protein FlgB-
BPHYT_RS189004246027..4247541+1515WP_012434709.1flagellar basal body P-ring formation protein FlgA-
BPHYT_RS189054247743..4248096+354WP_012434710.1flagellar biosynthesis anti-sigma factor FlgM-
BPHYT_RS189104248191..4248637+447WP_012434711.1flagellar protein FlgN-
BPHYT_RS189154248946..4249128+183WP_012434712.1type II toxin-antitoxin system HicA family toxinToxin
BPHYT_RS189204249125..4249535+411WP_012434713.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BPHYT_RS189254249596..4250330-735WP_012434714.1RNA polymerase sigma factor FliA-
BPHYT_RS189304250359..4251228-870WP_041758634.1AAA family ATPase-
BPHYT_RS189354251221..4253146-1926WP_041758636.1flagellar biosynthesis protein FlhF-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6629.78 Da        Isoelectric Point: 11.3940

>T22870 WP_012434712.1 NC_010681:4248946-4249128 [Paraburkholderia phytofirmans PsJN]
MKSAEVVKLIQTAGWQVVRITGSHHHFRHAERTGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T22870 NC_010681:4248946-4249128 [Paraburkholderia phytofirmans PsJN]
ATGAAAAGTGCCGAGGTCGTGAAACTCATTCAAACGGCGGGTTGGCAGGTGGTCCGCATAACGGGCAGCCACCATCATTT
TCGTCACGCGGAAAGAACCGGTCTCGTGACCATCCCGCATCCGAAGAAAGATCTTCCGCCCGGCACATTGAACAGCATCC
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14779.81 Da        Isoelectric Point: 4.6327

>AT22870 WP_012434713.1 NC_010681:4249125-4249535 [Paraburkholderia phytofirmans PsJN]
MKNLTFPIAIEPGSADHAFGVIVPDIPGCYAAGDTLEEAYANAKEAIEAHLDVLLDEGLPIPARRTLQEHRRNPDYADFT
WGLVATRNIPALKKAVRINISLPEALVQEIDAYAQARGMSRSAFLALAAEHEMAEA

Download         Length: 411 bp

>AT22870 NC_010681:4249125-4249535 [Paraburkholderia phytofirmans PsJN]
ATGAAGAACCTGACTTTCCCTATCGCGATCGAGCCGGGGAGCGCGGATCACGCGTTCGGCGTCATCGTGCCGGACATTCC
GGGCTGTTATGCGGCGGGCGATACGCTGGAAGAAGCCTACGCGAATGCCAAGGAGGCTATCGAGGCCCACCTTGACGTCC
TGCTCGACGAGGGCTTGCCGATTCCCGCGCGGCGTACGCTGCAAGAGCACCGGCGCAATCCCGACTATGCGGATTTCACG
TGGGGGCTTGTCGCCACCCGGAATATTCCCGCCTTGAAGAAGGCGGTACGTATCAATATCTCGCTGCCCGAAGCGCTGGT
CCAGGAGATCGACGCTTATGCCCAGGCGCGCGGCATGTCGCGCTCGGCCTTTCTGGCGCTGGCCGCGGAACATGAAATGG
CCGAGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBB2T7A5


Antitoxin

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Source
ID
Structure
AlphaFold DBB2T7A6

References