Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2370132..2370827 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ67_RS11060 Protein ID WP_003410811.1
Coordinates 2370132..2370566 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ67_RS11065 Protein ID WP_003410814.1
Coordinates 2370573..2370827 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS11050 (LVJ67_11055) 2366366..2369327 + 2962 Protein_2185 DEAD/DEAH box helicase -
LVJ67_RS11055 (LVJ67_11060) 2369320..2370153 + 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ67_RS11060 (LVJ67_11065) 2370132..2370566 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS11065 (LVJ67_11070) 2370573..2370827 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ67_RS11070 (LVJ67_11075) 2370843..2371100 - 258 WP_003410816.1 hypothetical protein -
LVJ67_RS11075 (LVJ67_11080) 2372047..2372343 + 297 WP_003410820.1 PE family protein -
LVJ67_RS11080 (LVJ67_11085) 2372399..2373130 + 732 WP_003900467.1 PPE family protein -
LVJ67_RS11085 (LVJ67_11090) 2373670..2374416 - 747 WP_003906749.1 proteasome subunit alpha -
LVJ67_RS11090 (LVJ67_11095) 2374413..2375288 - 876 WP_003411023.1 proteasome subunit beta -
LVJ67_RS11095 (LVJ67_11100) 2375285..2375479 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T228699 WP_003410811.1 NZ_CP089772:c2370566-2370132 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T228699 NZ_CP124337:976016-976423 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT228699 WP_003410814.1 NZ_CP089772:c2370827-2370573 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT228699 NZ_CP124337:975769-976035 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References