Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 2235364..2235950 | Replicon | chromosome |
| Accession | NZ_CP089772 | ||
| Organism | Mycobacterium tuberculosis strain I0003165-3 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G0TLY3 |
| Locus tag | LVJ67_RS10470 | Protein ID | WP_003410010.1 |
| Coordinates | 2235364..2235708 (-) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | P0CL58 |
| Locus tag | LVJ67_RS10475 | Protein ID | WP_003410014.1 |
| Coordinates | 2235702..2235950 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ67_RS10435 (LVJ67_10440) | 2231070..2231669 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
| LVJ67_RS10440 (LVJ67_10445) | 2232085..2232513 | + | 429 | WP_003906713.1 | cellulose-binding protein | - |
| LVJ67_RS10445 (LVJ67_10450) | 2232739..2233278 | + | 540 | WP_003900446.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) | - |
| LVJ67_RS10450 (LVJ67_10455) | 2233798..2234358 | - | 561 | WP_003410001.1 | RES family NAD+ phosphorylase | - |
| LVJ67_RS10455 (LVJ67_10460) | 2234355..2234696 | - | 342 | WP_003410003.1 | DUF2384 domain-containing protein | - |
| LVJ67_RS10460 (LVJ67_10465) | 2234782..2235039 | + | 258 | WP_003410006.1 | hypothetical protein | - |
| LVJ67_RS10465 (LVJ67_10470) | 2234940..2235275 | - | 336 | WP_003410009.1 | dehydrogenase | - |
| LVJ67_RS10470 (LVJ67_10475) | 2235364..2235708 | - | 345 | WP_003410010.1 | type II toxin-antitoxin system toxin endoribonuclease MazF6 | Toxin |
| LVJ67_RS10475 (LVJ67_10480) | 2235702..2235950 | - | 249 | WP_003410014.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| LVJ67_RS10480 (LVJ67_10485) | 2236050..2238365 | - | 2316 | WP_003899120.1 | cation transporter ATPase CptG | - |
| LVJ67_RS10485 (LVJ67_10490) | 2238362..2238634 | - | 273 | WP_003410017.1 | DUF1490 family protein | - |
| LVJ67_RS10490 (LVJ67_10495) | 2238687..2239043 | - | 357 | WP_003410018.1 | Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR | - |
| LVJ67_RS10495 (LVJ67_10500) | 2239200..2239967 | + | 768 | WP_003410019.1 | hemerythrin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12230.12 Da Isoelectric Point: 9.8887
>T228695 WP_003410010.1 NZ_CP089772:c2235708-2235364 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL
Download Length: 345 bp
>T228695 NZ_CP124337:291052-291579 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9290.34 Da Isoelectric Point: 4.3757
>AT228695 WP_003410014.1 NZ_CP089772:c2235950-2235702 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW
Download Length: 249 bp
>AT228695 NZ_CP124337:290779-291045 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|