228693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2226472..2227160 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag LVJ67_RS10405 Protein ID WP_003409958.1
Coordinates 2226472..2226891 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag LVJ67_RS10410 Protein ID WP_003409968.1
Coordinates 2226900..2227160 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS10385 (LVJ67_10390) 2221967..2222815 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
LVJ67_RS10390 (LVJ67_10395) 2222778..2224223 - 1446 WP_003899115.1 APC family permease -
LVJ67_RS10395 (LVJ67_10400) 2224402..2225088 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
LVJ67_RS10400 (LVJ67_10405) 2225279..2226247 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
LVJ67_RS10405 (LVJ67_10410) 2226472..2226891 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS10410 (LVJ67_10415) 2226900..2227160 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ67_RS10415 (LVJ67_10420) 2227303..2228979 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
LVJ67_RS10420 (LVJ67_10425) 2228967..2229620 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ67_RS10425 (LVJ67_10430) 2229735..2229965 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ67_RS10430 (LVJ67_10435) 2230050..2230961 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ67_RS10435 (LVJ67_10440) 2231070..2231669 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T228693 WP_003409958.1 NZ_CP089772:c2226891-2226472 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T228693 NZ_CP124337:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT228693 WP_003409968.1 NZ_CP089772:c2227160-2226900 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT228693 NZ_CP124337:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References