Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2204739..2205283 | Replicon | chromosome |
| Accession | NZ_CP089772 | ||
| Organism | Mycobacterium tuberculosis strain I0003165-3 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LVJ67_RS10285 | Protein ID | WP_003409896.1 |
| Coordinates | 2204739..2205035 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | LVJ67_RS10290 | Protein ID | WP_003409899.1 |
| Coordinates | 2205032..2205283 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ67_RS10230 (LVJ67_10235) | 2199772..2200122 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ67_RS10235 (LVJ67_10240) | 2200133..2201035 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ67_RS10240 (LVJ67_10245) | 2201056..2201247 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ67_RS10245 (LVJ67_10250) | 2201248..2201544 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ67_RS10250 (LVJ67_10255) | 2201784..2201999 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ67_RS10255 (LVJ67_10260) | 2201996..2202307 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ67_RS10260 (LVJ67_10265) | 2202281..2202802 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ67_RS10265 (LVJ67_10270) | 2202777..2203154 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LVJ67_RS10270 (LVJ67_10275) | 2203196..2203645 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LVJ67_RS10275 (LVJ67_10280) | 2203642..2204187 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ67_RS10280 (LVJ67_10285) | 2204076..2204690 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ67_RS10285 (LVJ67_10290) | 2204739..2205035 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ67_RS10290 (LVJ67_10295) | 2205032..2205283 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LVJ67_RS10295 (LVJ67_10300) | 2205270..2205764 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ67_RS10300 (LVJ67_10305) | 2205924..2206331 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ67_RS10305 (LVJ67_10310) | 2206335..2206607 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ67_RS10310 (LVJ67_10315) | 2206640..2207860 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ67_RS10315 (LVJ67_10320) | 2208759..2209556 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T228692 WP_003409896.1 NZ_CP089772:c2205035-2204739 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T228692 NZ_CP124335:c115594-115289 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT228692 WP_003409899.1 NZ_CP089772:c2205283-2205032 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT228692 NZ_CP124335:c115814-115596 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |