Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1962093..1962553 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag LVJ67_RS09165 Protein ID WP_003898996.1
Coordinates 1962305..1962553 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LVJ67_RS09160 Protein ID WP_003408528.1
Coordinates 1962093..1962305 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS09145 (LVJ67_09145) 1958571..1959758 - 1188 WP_003898992.1 nitrate transporter NarK -
LVJ67_RS09150 (LVJ67_09150) 1960045..1960329 + 285 WP_003408522.1 DUF1876 domain-containing protein -
LVJ67_RS09155 (LVJ67_09155) 1960343..1962025 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
LVJ67_RS09160 (LVJ67_09160) 1962093..1962305 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ67_RS09165 (LVJ67_09165) 1962305..1962553 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS09170 (LVJ67_09170) 1962561..1963298 + 738 WP_003898997.1 hypothetical protein -
LVJ67_RS09175 (LVJ67_09175) 1963392..1965092 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LVJ67_RS09180 (LVJ67_09180) 1965377..1965778 - 402 WP_003408538.1 hypothetical protein -
LVJ67_RS09185 (LVJ67_09185) 1965768..1966379 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T228689 WP_003898996.1 NZ_CP089772:1962305-1962553 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T228689 NZ_CP124334:4956981-4957232 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT228689 WP_003408528.1 NZ_CP089772:1962093-1962305 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT228689 NZ_CP124334:4957229-4957483 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References