Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1941304..1941917 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ67_RS09055 Protein ID WP_003408465.1
Coordinates 1941304..1941693 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ67_RS09060 Protein ID WP_003408469.1
Coordinates 1941690..1941917 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS09020 (LVJ67_09020) 1936934..1937848 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ67_RS09025 (LVJ67_09025) 1937851..1938681 + 831 WP_003906661.1 cyclase family protein -
LVJ67_RS09030 (LVJ67_09030) 1938681..1939030 + 350 Protein_1782 cupin domain-containing protein -
LVJ67_RS09035 (LVJ67_09035) 1939083..1939901 + 819 WP_031697633.1 3-keto-5-aminohexanoate cleavage protein -
LVJ67_RS09040 (LVJ67_09040) 1939915..1940694 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ67_RS09050 (LVJ67_09050) 1941125..1941256 + 132 Protein_1785 IS3 family transposase -
LVJ67_RS09055 (LVJ67_09055) 1941304..1941693 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS09060 (LVJ67_09060) 1941690..1941917 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ67_RS09065 (LVJ67_09065) 1942135..1943619 + 1485 WP_072492580.1 biotin carboxylase -
LVJ67_RS09070 (LVJ67_09070) 1943616..1944863 + 1248 WP_003408476.1 serine hydrolase -
LVJ67_RS09075 (LVJ67_09075) 1944906..1945325 - 420 WP_003408483.1 hypothetical protein -
LVJ67_RS09080 (LVJ67_09080) 1945315..1946025 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T228688 WP_003408465.1 NZ_CP089772:c1941693-1941304 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T228688 NZ_CP124334:3933853-3934260 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT228688 WP_003408469.1 NZ_CP089772:c1941917-1941690 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT228688 NZ_CP124334:3933606-3933872 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References