Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1392084..1392643 | Replicon | chromosome |
| Accession | NZ_CP089772 | ||
| Organism | Mycobacterium tuberculosis strain I0003165-3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0THS1 |
| Locus tag | LVJ67_RS06650 | Protein ID | WP_003898789.1 |
| Coordinates | 1392084..1392377 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0THS2 |
| Locus tag | LVJ67_RS06655 | Protein ID | WP_003406322.1 |
| Coordinates | 1392374..1392643 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ67_RS06625 (LVJ67_06615) | 1387677..1387937 | + | 261 | WP_003406302.1 | type II toxin-antitoxin system antitoxin VapB33 | - |
| LVJ67_RS06630 (LVJ67_06620) | 1387934..1388365 | + | 432 | WP_003406304.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ67_RS06635 (LVJ67_06625) | 1388388..1390076 | - | 1689 | WP_003910308.1 | PE family protein | - |
| LVJ67_RS06640 (LVJ67_06630) | 1390256..1391116 | + | 861 | WP_003900301.1 | glycine betaine ABC transporter substrate-binding protein | - |
| LVJ67_RS06645 (LVJ67_06635) | 1391197..1392027 | - | 831 | WP_003898788.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| LVJ67_RS06650 (LVJ67_06640) | 1392084..1392377 | - | 294 | WP_003898789.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LVJ67_RS06655 (LVJ67_06645) | 1392374..1392643 | - | 270 | WP_003406322.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LVJ67_RS06660 (LVJ67_06650) | 1392756..1396451 | - | 3696 | WP_009938349.1 | multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit | - |
| LVJ67_RS06665 (LVJ67_06655) | 1396593..1397381 | - | 789 | WP_003406325.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11031.57 Da Isoelectric Point: 9.6275
>T228683 WP_003898789.1 NZ_CP089772:c1392377-1392084 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR
Download Length: 294 bp
>T228683 NZ_CP124334:3146378-3146485 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9766.97 Da Isoelectric Point: 4.8615
>AT228683 WP_003406322.1 NZ_CP089772:c1392643-1392374 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR
Download Length: 270 bp
>AT228683 NZ_CP124334:c3146321-3146264 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|