Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1387677..1388365 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag LVJ67_RS06630 Protein ID WP_003406304.1
Coordinates 1387934..1388365 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag LVJ67_RS06625 Protein ID WP_003406302.1
Coordinates 1387677..1387937 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS06605 (LVJ67_06595) 1383254..1384078 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
LVJ67_RS06610 (LVJ67_06600) 1384083..1385264 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
LVJ67_RS06615 (LVJ67_06605) 1385341..1386441 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
LVJ67_RS06620 (LVJ67_06610) 1386612..1387601 + 990 WP_003406301.1 malate dehydrogenase -
LVJ67_RS06625 (LVJ67_06615) 1387677..1387937 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
LVJ67_RS06630 (LVJ67_06620) 1387934..1388365 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS06635 (LVJ67_06625) 1388388..1390076 - 1689 WP_003910308.1 PE family protein -
LVJ67_RS06640 (LVJ67_06630) 1390256..1391116 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
LVJ67_RS06645 (LVJ67_06635) 1391197..1392027 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
LVJ67_RS06650 (LVJ67_06640) 1392084..1392377 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
LVJ67_RS06655 (LVJ67_06645) 1392374..1392643 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T228682 WP_003406304.1 NZ_CP089772:1387934-1388365 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T228682 NZ_CP124334:3145895-3146002 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT228682 WP_003406302.1 NZ_CP089772:1387677-1387937 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT228682 NZ_CP124334:c3145846-3145781 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References