Detailed information of TA system TA022867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 171763..172442
• Replicon: chromosome
• Accession: NC_010681
• Organism: Burkholderia phytofirmans PsJN

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HB51
• Locus tag: BPHYT_RS00745
• Protein ID: WP_012431246.1
• Coordinates: 171763..172167 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BPHYT_RS00750
• Protein ID: WP_202945179.1
• Coordinates: 172164..172442 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPHYT_RS00720	167570..168997	+	1428	WP_012431241.1	amidase	-
BPHYT_RS00725	168994..169539	+	546	WP_012431242.1	amino acid synthesis family protein	-
BPHYT_RS00730	169621..170655	+	1035	WP_012431243.1	porin	-
BPHYT_RS00735	170907..171149	+	243	WP_012431244.1	AlpA family transcriptional regulator	-
BPHYT_RS00740	171146..171472	+	327	WP_012431245.1	hypothetical protein	-
BPHYT_RS00745	171763..172167	-	405	WP_012431246.1	type II toxin-antitoxin system VapC family toxin	Toxin
BPHYT_RS00750	172164..172442	-	279	WP_202945179.1	antitoxin	Antitoxin
BPHYT_RS00755	172963..173835	+	873	WP_012431248.1	ParA family protein	-
BPHYT_RS00760	173828..174412	+	585	WP_012431249.1	hypothetical protein	-
BPHYT_RS00765	174409..175086	+	678	WP_012431250.1	lytic transglycosylase domain-containing protein	-
BPHYT_RS00770	175124..175465	+	342	WP_039339345.1	TrbC/VirB2 family protein	-
BPHYT_RS00775	175479..175811	+	333	WP_012431252.1	VirB3 family type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (18-56)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14466.86 Da
• Isoelectric Point: 6.4531

>T22867 WP_012431246.1 NC_010681:c172167-171763 [Paraburkholderia phytofirmans PsJN]
MNGYLLDTNVIRDMIRYPSGKVATHIGQIDPRAICTSVVVAAELRYGCARKGSEKLLARVESLLAIIPVLPLDVPADTEY
GGIRAELEIAGQPIGANELLIAAHACALGLTLVTDNTKVFSRIRGLAIENWLDR

Nucleotide

• Length: 405 bp

>T22867 NC_010681:c172167-171763 [Paraburkholderia phytofirmans PsJN]
TTGAACGGCTATCTGCTGGACACGAACGTCATCCGCGACATGATCCGCTATCCGTCCGGAAAGGTGGCCACCCATATCGG
GCAAATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCCAGAAAGGGTTCCG
AAAAATTGCTGGCCAGAGTGGAAAGCCTGCTTGCGATCATTCCCGTGCTGCCGCTGGACGTGCCTGCTGACACCGAATAC
GGGGGTATTCGTGCAGAGCTTGAGATTGCTGGCCAGCCGATCGGTGCAAACGAGCTTCTGATCGCGGCTCATGCCTGTGC
GTTGGGGCTCACACTCGTGACTGACAACACGAAGGTGTTCAGCCGCATACGCGGTCTTGCGATCGAGAACTGGCTTGACC
GGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10566.11 Da
• Isoelectric Point: 4.5112

>AT22867 WP_202945179.1 NC_010681:c172442-172164 [Paraburkholderia phytofirmans PsJN]
MIMPVPPPSGRPREARLFRNNRSQAVRIPVEFELPGDRVLIYREGDRLIIEPVKTPANIIELLDAWRQEPRFGPDDQFPD
IEDAPLQPEGIP

Nucleotide

• Length: 279 bp

>AT22867 NC_010681:c172442-172164 [Paraburkholderia phytofirmans PsJN]
ATGATCATGCCCGTGCCCCCTCCTTCCGGCCGCCCCAGGGAGGCCAGACTGTTCCGCAACAACCGGAGTCAGGCGGTACG
CATCCCGGTCGAATTCGAGTTGCCGGGTGATCGCGTCCTGATCTATCGGGAGGGCGACAGGCTCATCATCGAGCCGGTGA
AAACCCCCGCGAACATCATCGAATTGCTGGATGCATGGAGACAGGAGCCACGGTTCGGACCTGACGACCAGTTTCCGGAT
ATTGAGGATGCGCCTCTTCAGCCGGAGGGCATACCTTGA

Structures

Toxin

• AlphaFold DB: U2HB51