22867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 171763..172442 Replicon chromosome
Accession NC_010681
Organism Burkholderia phytofirmans PsJN

Toxin (Protein)


Gene name vapC Uniprot ID U2HB51
Locus tag BPHYT_RS00745 Protein ID WP_012431246.1
Coordinates 171763..172167 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BPHYT_RS00750 Protein ID WP_202945179.1
Coordinates 172164..172442 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPHYT_RS00720 167570..168997 + 1428 WP_012431241.1 amidase -
BPHYT_RS00725 168994..169539 + 546 WP_012431242.1 amino acid synthesis family protein -
BPHYT_RS00730 169621..170655 + 1035 WP_012431243.1 porin -
BPHYT_RS00735 170907..171149 + 243 WP_012431244.1 AlpA family transcriptional regulator -
BPHYT_RS00740 171146..171472 + 327 WP_012431245.1 hypothetical protein -
BPHYT_RS00745 171763..172167 - 405 WP_012431246.1 type II toxin-antitoxin system VapC family toxin Toxin
BPHYT_RS00750 172164..172442 - 279 WP_202945179.1 antitoxin Antitoxin
BPHYT_RS00755 172963..173835 + 873 WP_012431248.1 ParA family protein -
BPHYT_RS00760 173828..174412 + 585 WP_012431249.1 hypothetical protein -
BPHYT_RS00765 174409..175086 + 678 WP_012431250.1 lytic transglycosylase domain-containing protein -
BPHYT_RS00770 175124..175465 + 342 WP_039339345.1 TrbC/VirB2 family protein -
BPHYT_RS00775 175479..175811 + 333 WP_012431252.1 VirB3 family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14466.86 Da        Isoelectric Point: 6.4531

>T22867 WP_012431246.1 NC_010681:c172167-171763 [Paraburkholderia phytofirmans PsJN]
MNGYLLDTNVIRDMIRYPSGKVATHIGQIDPRAICTSVVVAAELRYGCARKGSEKLLARVESLLAIIPVLPLDVPADTEY
GGIRAELEIAGQPIGANELLIAAHACALGLTLVTDNTKVFSRIRGLAIENWLDR

Download         Length: 405 bp

>T22867 NC_010681:c172167-171763 [Paraburkholderia phytofirmans PsJN]
TTGAACGGCTATCTGCTGGACACGAACGTCATCCGCGACATGATCCGCTATCCGTCCGGAAAGGTGGCCACCCATATCGG
GCAAATTGATCCCAGGGCGATCTGCACGAGCGTCGTCGTCGCGGCGGAACTGCGCTATGGCTGTGCCAGAAAGGGTTCCG
AAAAATTGCTGGCCAGAGTGGAAAGCCTGCTTGCGATCATTCCCGTGCTGCCGCTGGACGTGCCTGCTGACACCGAATAC
GGGGGTATTCGTGCAGAGCTTGAGATTGCTGGCCAGCCGATCGGTGCAAACGAGCTTCTGATCGCGGCTCATGCCTGTGC
GTTGGGGCTCACACTCGTGACTGACAACACGAAGGTGTTCAGCCGCATACGCGGTCTTGCGATCGAGAACTGGCTTGACC
GGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10566.11 Da        Isoelectric Point: 4.5112

>AT22867 WP_202945179.1 NC_010681:c172442-172164 [Paraburkholderia phytofirmans PsJN]
MIMPVPPPSGRPREARLFRNNRSQAVRIPVEFELPGDRVLIYREGDRLIIEPVKTPANIIELLDAWRQEPRFGPDDQFPD
IEDAPLQPEGIP

Download         Length: 279 bp

>AT22867 NC_010681:c172442-172164 [Paraburkholderia phytofirmans PsJN]
ATGATCATGCCCGTGCCCCCTCCTTCCGGCCGCCCCAGGGAGGCCAGACTGTTCCGCAACAACCGGAGTCAGGCGGTACG
CATCCCGGTCGAATTCGAGTTGCCGGGTGATCGCGTCCTGATCTATCGGGAGGGCGACAGGCTCATCATCGAGCCGGTGA
AAACCCCCGCGAACATCATCGAATTGCTGGATGCATGGAGACAGGAGCCACGGTTCGGACCTGACGACCAGTTTCCGGAT
ATTGAGGATGCGCCTCTTCAGCCGGAGGGCATACCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2HB51

Antitoxin

Source ID Structure

References