Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704631..705274 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ67_RS03200 Protein ID WP_003403187.1
Coordinates 704873..705274 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ67_RS03195 Protein ID WP_003403184.1
Coordinates 704631..704876 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS03160 (LVJ67_03155) 699911..700441 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ67_RS03165 (LVJ67_03160) 700425..701120 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ67_RS03170 (LVJ67_03165) 701243..701554 + 312 WP_003403164.1 hypothetical protein -
LVJ67_RS03175 (LVJ67_03170) 701626..702576 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ67_RS03180 (LVJ67_03175) 702817..703401 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ67_RS03185 (LVJ67_03180) 703403..704113 + 711 Protein_631 IS607 family element RNA-guided endonuclease TnpB -
LVJ67_RS03190 (LVJ67_03185) 704116..704586 + 471 WP_003898523.1 hypothetical protein -
LVJ67_RS03195 (LVJ67_03190) 704631..704876 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ67_RS03200 (LVJ67_03195) 704873..705274 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ67_RS03205 (LVJ67_03200) 705265..705444 + 180 Protein_635 hypothetical protein -
LVJ67_RS03210 (LVJ67_03205) 705862..706059 - 198 WP_003403191.1 hypothetical protein -
LVJ67_RS03215 (LVJ67_03210) 706139..707296 - 1158 WP_003898524.1 hypothetical protein -
LVJ67_RS03220 (LVJ67_03215) 707348..707569 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ67_RS03225 (LVJ67_03220) 707711..708316 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228668 WP_003403187.1 NZ_CP089772:704873-705274 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228668 NZ_CP124333:c32901-32752 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228668 WP_003403184.1 NZ_CP089772:704631-704876 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228668 NZ_CP124333:32945-33006 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References