Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 704631..705274 | Replicon | chromosome |
Accession | NZ_CP089772 | ||
Organism | Mycobacterium tuberculosis strain I0003165-3 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P67239 |
Locus tag | LVJ67_RS03200 | Protein ID | WP_003403187.1 |
Coordinates | 704873..705274 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ91 |
Locus tag | LVJ67_RS03195 | Protein ID | WP_003403184.1 |
Coordinates | 704631..704876 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ67_RS03160 (LVJ67_03155) | 699911..700441 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
LVJ67_RS03165 (LVJ67_03160) | 700425..701120 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
LVJ67_RS03170 (LVJ67_03165) | 701243..701554 | + | 312 | WP_003403164.1 | hypothetical protein | - |
LVJ67_RS03175 (LVJ67_03170) | 701626..702576 | + | 951 | WP_003900184.1 | DUF1259 domain-containing protein | - |
LVJ67_RS03180 (LVJ67_03175) | 702817..703401 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
LVJ67_RS03185 (LVJ67_03180) | 703403..704113 | + | 711 | Protein_631 | IS607 family element RNA-guided endonuclease TnpB | - |
LVJ67_RS03190 (LVJ67_03185) | 704116..704586 | + | 471 | WP_003898523.1 | hypothetical protein | - |
LVJ67_RS03195 (LVJ67_03190) | 704631..704876 | + | 246 | WP_003403184.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LVJ67_RS03200 (LVJ67_03195) | 704873..705274 | + | 402 | WP_003403187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LVJ67_RS03205 (LVJ67_03200) | 705265..705444 | + | 180 | Protein_635 | hypothetical protein | - |
LVJ67_RS03210 (LVJ67_03205) | 705862..706059 | - | 198 | WP_003403191.1 | hypothetical protein | - |
LVJ67_RS03215 (LVJ67_03210) | 706139..707296 | - | 1158 | WP_003898524.1 | hypothetical protein | - |
LVJ67_RS03220 (LVJ67_03215) | 707348..707569 | - | 222 | WP_003898525.1 | DUF4926 domain-containing protein | - |
LVJ67_RS03225 (LVJ67_03220) | 707711..708316 | + | 606 | WP_003898526.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14501.21 Da Isoelectric Point: 4.4463
>T228668 WP_003403187.1 NZ_CP089772:704873-705274 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
Download Length: 402 bp
>T228668 NZ_CP124333:c32901-32752 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8813.12 Da Isoelectric Point: 10.3486
>AT228668 WP_003403184.1 NZ_CP089772:704631-704876 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
Download Length: 246 bp
>AT228668 NZ_CP124333:32945-33006 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ91 |