Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
Location | 698541..699187 | Replicon | chromosome |
Accession | NZ_CP089772 | ||
Organism | Mycobacterium tuberculosis strain I0003165-3 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ88 |
Locus tag | LVJ67_RS03145 | Protein ID | WP_003403137.1 |
Coordinates | 698541..698954 (-) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ89 |
Locus tag | LVJ67_RS03150 | Protein ID | WP_003403139.1 |
Coordinates | 698951..699187 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LVJ67_RS03125 (LVJ67_03120) | 694624..696174 | + | 1551 | WP_003403119.1 | MlaD family protein | - |
LVJ67_RS03130 (LVJ67_03125) | 696226..696618 | - | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
LVJ67_RS03135 (LVJ67_03130) | 696615..696872 | - | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
LVJ67_RS03140 (LVJ67_03135) | 697055..698290 | - | 1236 | WP_003403128.1 | ATP-binding protein | - |
LVJ67_RS03145 (LVJ67_03140) | 698541..698954 | - | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LVJ67_RS03150 (LVJ67_03145) | 698951..699187 | - | 237 | WP_003403139.1 | type II toxin-antitoxin system antitoxin VapB27 | Antitoxin |
LVJ67_RS03155 (LVJ67_03150) | 699291..699797 | - | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
LVJ67_RS03160 (LVJ67_03155) | 699911..700441 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
LVJ67_RS03165 (LVJ67_03160) | 700425..701120 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
LVJ67_RS03170 (LVJ67_03165) | 701243..701554 | + | 312 | WP_003403164.1 | hypothetical protein | - |
LVJ67_RS03175 (LVJ67_03170) | 701626..702576 | + | 951 | WP_003900184.1 | DUF1259 domain-containing protein | - |
LVJ67_RS03180 (LVJ67_03175) | 702817..703401 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
LVJ67_RS03185 (LVJ67_03180) | 703403..704113 | + | 711 | Protein_631 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T228667 WP_003403137.1 NZ_CP089772:c698954-698541 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
>T228667 NZ_CP124332:c5212550-5212443 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8212.41 Da Isoelectric Point: 5.0351
>AT228667 WP_003403139.1 NZ_CP089772:c699187-698951 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
Download Length: 237 bp
>AT228667 NZ_CP124332:5212598-5212664 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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