228663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 448147..449158 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name pezT Uniprot ID A0A655I6S7
Locus tag LVJ67_RS01945 Protein ID WP_003906352.1
Coordinates 448147..448740 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ67_RS01950 Protein ID WP_003401860.1
Coordinates 448769..449158 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS01925 (LVJ67_01925) 443796..445178 + 1383 WP_003898415.1 magnesium transporter -
LVJ67_RS01930 (LVJ67_01930) 445190..446224 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ67_RS01935 (LVJ67_01935) 446320..447003 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ67_RS01940 (LVJ67_01940) 446992..448122 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LVJ67_RS01945 (LVJ67_01945) 448147..448740 - 594 WP_003906352.1 zeta toxin family protein Toxin
LVJ67_RS01950 (LVJ67_01950) 448769..449158 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ67_RS01955 (LVJ67_01955) 449239..450450 - 1212 WP_003906353.1 VWA domain-containing protein -
LVJ67_RS01960 (LVJ67_01960) 450456..451058 - 603 WP_003898417.1 SRPBCC family protein -
LVJ67_RS01965 (LVJ67_01965) 451072..451968 - 897 WP_003898418.1 MoxR family ATPase -
LVJ67_RS01970 (LVJ67_01970) 451965..452558 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ67_RS01975 (LVJ67_01975) 452555..453310 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21358.60 Da        Isoelectric Point: 10.6337

>T228663 WP_003906352.1 NZ_CP089772:c448740-448147 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDKSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T228663 NZ_CP124332:3880427-3880711 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT228663 WP_003401860.1 NZ_CP089772:c449158-448769 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT228663 NZ_CP124332:3880191-3880424 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A655I6S7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References