Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 367760..368403 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag LVJ67_RS01605 Protein ID WP_003401566.1
Coordinates 367978..368403 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag LVJ67_RS01600 Protein ID WP_003401563.1
Coordinates 367760..367981 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS01575 (LVJ67_01575) 362879..363682 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ67_RS01580 (LVJ67_01580) 363692..365089 - 1398 WP_003401544.1 sulfatase -
LVJ67_RS01585 (LVJ67_01585) 365268..367043 + 1776 WP_010886074.1 PE family protein -
LVJ67_RS01590 (LVJ67_01590) 367186..367413 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
LVJ67_RS01595 (LVJ67_01595) 367410..367712 + 303 WP_003401560.1 toxin-antitoxin system toxin -
LVJ67_RS01600 (LVJ67_01600) 367760..367981 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LVJ67_RS01605 (LVJ67_01605) 367978..368403 + 426 WP_003401566.1 PIN domain nuclease Toxin
LVJ67_RS01610 (LVJ67_01610) 368539..369171 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ67_RS01615 (LVJ67_01615) 369168..370076 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ67_RS01620 (LVJ67_01620) 370084..370674 - 591 WP_229298012.1 hypothetical protein -
LVJ67_RS01625 (LVJ67_01625) 370667..370717 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T228662 WP_003401566.1 NZ_CP089772:367978-368403 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T228662 NZ_CP124332:3770386-3770673 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT228662 WP_003401563.1 NZ_CP089772:367760-367981 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT228662 NZ_CP124332:3770660-3770962 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References