Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 367186..367712 Replicon chromosome
Accession NZ_CP089772
Organism Mycobacterium tuberculosis strain I0003165-3

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag LVJ67_RS01595 Protein ID WP_003401560.1
Coordinates 367410..367712 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag LVJ67_RS01590 Protein ID WP_003401555.1
Coordinates 367186..367413 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ67_RS01575 (LVJ67_01575) 362879..363682 - 804 WP_003401540.1 Stf0 family sulphotransferase -
LVJ67_RS01580 (LVJ67_01580) 363692..365089 - 1398 WP_003401544.1 sulfatase -
LVJ67_RS01585 (LVJ67_01585) 365268..367043 + 1776 WP_010886074.1 PE family protein -
LVJ67_RS01590 (LVJ67_01590) 367186..367413 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
LVJ67_RS01595 (LVJ67_01595) 367410..367712 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
LVJ67_RS01600 (LVJ67_01600) 367760..367981 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
LVJ67_RS01605 (LVJ67_01605) 367978..368403 + 426 WP_003401566.1 PIN domain nuclease -
LVJ67_RS01610 (LVJ67_01610) 368539..369171 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
LVJ67_RS01615 (LVJ67_01615) 369168..370076 + 909 WP_003900117.1 protochlorophyllide reductase -
LVJ67_RS01620 (LVJ67_01620) 370084..370674 - 591 WP_229298012.1 hypothetical protein -
LVJ67_RS01625 (LVJ67_01625) 370667..370717 - 51 Protein_321 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T228660 WP_003401560.1 NZ_CP089772:367410-367712 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T228660 NZ_CP124332:3590167-3590517 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT228660 WP_003401555.1 NZ_CP089772:367186-367413 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT228660 NZ_CP124332:3589922-3590173 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References