Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3441820..3443595 Replicon chromosome
Accession NC_010676
Organism Burkholderia phytofirmans PsJN

Toxin (Protein)


Gene name doc Uniprot ID B2TA48
Locus tag BPHYT_RS34955 Protein ID WP_012428846.1
Coordinates 3441820..3442710 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B2TA49
Locus tag BPHYT_RS34960 Protein ID WP_012428847.1
Coordinates 3442711..3443595 (+) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPHYT_RS34925 3437175..3438248 - 1074 WP_012428840.1 porin -
BPHYT_RS34930 3438690..3439004 + 315 WP_012428841.1 non-heme iron oxygenase ferredoxin subunit -
BPHYT_RS34935 3439006..3439317 + 312 WP_012428842.1 hypothetical protein -
BPHYT_RS34940 3439366..3440460 + 1095 WP_012428843.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BPHYT_RS34945 3440453..3441220 + 768 WP_012428844.1 SDR family oxidoreductase -
BPHYT_RS34950 3441247..3441774 + 528 WP_012428845.1 cupin domain-containing protein -
BPHYT_RS34955 3441820..3442710 + 891 WP_012428846.1 alpha/beta fold hydrolase Toxin
BPHYT_RS34960 3442711..3443595 + 885 WP_012428847.1 IclR family transcriptional regulator Antitoxin
BPHYT_RS34965 3443595..3444392 + 798 WP_012428848.1 SDR family oxidoreductase -
BPHYT_RS34970 3444385..3446043 + 1659 WP_012428849.1 thiamine pyrophosphate-binding protein -
BPHYT_RS34975 3446036..3446866 + 831 WP_012428850.1 aspartate dehydrogenase -
BPHYT_RS34980 3446907..3448397 + 1491 WP_012428851.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(148-272)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30962.16 Da        Isoelectric Point: 8.2903

>T22866 WP_012428846.1 NC_010676:3441820-3442710 [Paraburkholderia phytofirmans PsJN]
MSAVPSVTADQHATLEARLARFPAQQVRLATQRAVSYREVDSAGSSALPLVLLHGIGSGAASWVQQFEGLGATRRVLAWD
APGYGASTPVVAGSPAAADYASLLKEWLDALGIERCVLLGHSLGAIIAGAFAVAHPQRVAGLLLLSPAGGYGAASAELRN
AKRDQRLAMLNELGPQGLAEKRSANMLSAHASDEARAWVRWNMSRVIPHGYAQATHLLANADLAGDLARFKGRINVAVGA
DDTITTPEACERLALAAGTKLQVVPRAGHAGYIEAPAAYTAIIDTFCRTSDGQRSQ

Download         Length: 891 bp

>T22866 NC_010676:3441820-3442710 [Paraburkholderia phytofirmans PsJN]
ATGTCCGCAGTCCCGTCCGTTACAGCCGATCAACACGCTACGCTCGAAGCCCGCCTTGCGCGCTTTCCGGCGCAGCAGGT
CCGGCTGGCCACGCAACGCGCGGTGAGCTATCGCGAAGTGGATAGCGCCGGCAGCAGCGCGTTGCCGCTCGTGCTGCTGC
ACGGTATCGGGTCGGGCGCGGCGTCGTGGGTGCAGCAGTTCGAGGGACTCGGCGCGACGCGCCGCGTGCTGGCATGGGAT
GCGCCGGGTTATGGCGCATCTACGCCGGTCGTGGCCGGATCTCCCGCCGCAGCCGATTACGCGAGTTTGTTGAAGGAGTG
GCTGGACGCGCTCGGCATCGAACGCTGCGTGCTGCTCGGCCATTCGCTCGGCGCGATCATCGCCGGCGCGTTTGCGGTGG
CGCACCCGCAGCGTGTGGCCGGTTTGCTGCTGTTGTCGCCGGCTGGTGGATACGGCGCGGCCTCGGCGGAACTGCGTAAT
GCGAAGCGCGATCAGCGCCTTGCCATGCTGAACGAACTGGGCCCGCAAGGCCTTGCGGAAAAACGCAGCGCCAACATGCT
GTCCGCTCACGCGAGCGACGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGCGTGATCCCGCACGGCTACGCGCAGG
CCACGCATCTGCTCGCCAACGCCGATCTCGCCGGCGACCTCGCGCGCTTTAAAGGCCGCATCAACGTGGCCGTCGGCGCC
GACGACACCATTACGACGCCCGAAGCCTGCGAGCGACTCGCACTGGCCGCGGGCACCAAACTGCAAGTCGTGCCTCGCGC
GGGTCACGCCGGCTATATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGTCGTACAAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32715.18 Da        Isoelectric Point: 6.6637

>AT22866 WP_012428847.1 NC_010676:3442711-3443595 [Paraburkholderia phytofirmans PsJN]
MTPDTAHAEREADEDRNDTTGDTAYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNETGLTSHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGTRLPAY
ATTHGQVLMGDLTLDELKKLYPEPELERFTKQTPVTIDDLYERIRDDAQRGFAISESSFERGISVVSAPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKGGAKSGSNYMKALGL

Download         Length: 885 bp

>AT22866 NC_010676:3442711-3443595 [Paraburkholderia phytofirmans PsJN]
ATGACGCCCGACACTGCTCACGCCGAGCGCGAAGCGGACGAAGACCGCAACGACACCACTGGCGACACCGCCTATCGCGT
GCCCGGTCTCGAACGCGGTCTGAAGATTCTCACGGAGTTCTCGCCACGCGAGCCGGTTCTCGGTGCACCGGAATTATCCA
GGCGCCTGAAGATTCCTCGCACGACGGTGTTCCGTCTGTTGCAAACGCTCGAATCGCTCGGCTTTCTGGAGCGTGCCGAC
AAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTGCGGCTCGGTTTTGAATATCTGAGTTCGCTCGAATTAACCGACCT
CGGTTTGCCGATCATCGAGGCGTTGCGTAACGAAACCGGGCTGACCAGCCACATCGTGATTCGCGATGGACGCGATGTCG
TGTTCGTCGCCAAAGCGCAAAGCCACACGCCGATTTTCAGTTCGGTGAAGGTGAACGTGGGCACGCGTCTGCCGGCTTAC
GCCACGACGCACGGTCAGGTGCTAATGGGCGACCTGACGCTTGACGAACTGAAGAAGCTCTATCCCGAGCCCGAACTCGA
ACGTTTCACGAAGCAGACGCCGGTCACTATCGACGACCTGTACGAACGGATTCGCGACGACGCGCAGCGTGGTTTCGCGA
TCAGCGAGTCGTCGTTCGAGCGCGGTATTTCGGTGGTGAGCGCGCCGGTGCGCAACGACACAGGCCGCATCGTCGCCGTG
ATCACGACCACGATTCCGCGCCACGAGATCGACGCGTCGCTGCTCGACAGCGGCCTGATCGACAAGGTCCGCCGCGCGGC
CGACGAACTTTCGCAGCGGCTCAACTATCGGCCCAAGGGTGGCGCGAAGTCGGGCAGCAATTACATGAAGGCATTGGGGC
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B2TA48

Antitoxin

Source ID Structure
AlphaFold DB B2TA49

References