228648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2247871..2248490 Replicon chromosome
Accession NZ_CP089771
Organism Klebsiella pneumoniae strain HKE12

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVO50_RS10780 Protein ID WP_002892050.1
Coordinates 2247871..2248089 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVO50_RS10785 Protein ID WP_002892066.1
Coordinates 2248116..2248490 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO50_RS10745 (2243918) 2243918..2244181 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
LVO50_RS10750 (2244181) 2244181..2244321 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVO50_RS10755 (2244318) 2244318..2245016 - 699 WP_004177238.1 GNAT family protein -
LVO50_RS10760 (2245117) 2245117..2246568 + 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
LVO50_RS10765 (2246543) 2246543..2247013 - 471 WP_002892026.1 YlaC family protein -
LVO50_RS10770 (2247034) 2247034..2247174 + 141 WP_004147370.1 hypothetical protein -
LVO50_RS10775 (2247146) 2247146..2247712 - 567 WP_002892030.1 maltose O-acetyltransferase -
LVO50_RS10780 (2247871) 2247871..2248089 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LVO50_RS10785 (2248116) 2248116..2248490 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVO50_RS10790 (2248976) 2248976..2252122 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVO50_RS10795 (2252145) 2252145..2253338 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T228648 WP_002892050.1 NZ_CP089771:c2248089-2247871 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T228648 NZ_CP124332:c918934-918680 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT228648 WP_002892066.1 NZ_CP089771:c2248490-2248116 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT228648 NZ_CP124332:c919182-918931 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References