228646

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1586189..1587526 Replicon chromosome
Accession NZ_CP089771
Organism Klebsiella pneumoniae strain HKE12

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag LVO50_RS07630 Protein ID WP_032424556.1
Coordinates 1586189..1587124 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID -
Locus tag LVO50_RS07635 Protein ID WP_023302769.1
Coordinates 1587131..1587526 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO50_RS07615 (1582410) 1582410..1584089 + 1680 WP_004212561.1 tyrosine-type recombinase/integrase -
LVO50_RS07620 (1584610) 1584610..1585302 + 693 WP_223272586.1 RES family NAD+ phosphorylase -
LVO50_RS07625 (1585492) 1585492..1586181 + 690 WP_023302767.1 abortive infection system antitoxin AbiGi family protein -
LVO50_RS07630 (1586189) 1586189..1587124 - 936 WP_032424556.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LVO50_RS07635 (1587131) 1587131..1587526 - 396 WP_023302769.1 DUF6088 family protein Antitoxin
LVO50_RS07640 (1587781) 1587781..1588047 + 267 WP_023302770.1 hypothetical protein -
LVO50_RS07645 (1588053) 1588053..1588517 - 465 WP_022615700.1 GNAT family N-acetyltransferase -
LVO50_RS07650 (1588689) 1588689..1590284 - 1596 WP_023302771.1 MobH family relaxase -
LVO50_RS07655 (1590458) 1590458..1590829 - 372 WP_022615702.1 hypothetical protein -
LVO50_RS07660 (1591022) 1591022..1591927 - 906 WP_022615703.1 zincin-like metallopeptidase domain-containing protein -
LVO50_RS07665 (1591992) 1591992..1592282 - 291 WP_022615704.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-298)

Antitoxin

Protein of unknown function DUF6088

(7-109)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35389.66 Da        Isoelectric Point: 5.6165

>T228646 WP_032424556.1 NZ_CP089771:c1587124-1586189 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Download         Length: 936 bp

>T228646 NZ_CP124332:c515042-514940 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14800.08 Da        Isoelectric Point: 11.1078

>AT228646 WP_023302769.1 NZ_CP089771:c1587526-1587131 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Download         Length: 396 bp

>AT228646 NZ_CP124332:514902-515170 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References