Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 162068..162725 Replicon chromosome
Accession NZ_CP089771
Organism Klebsiella pneumoniae strain HKE12

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVO50_RS00760 Protein ID WP_002916310.1
Coordinates 162068..162478 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVO50_RS00765 Protein ID WP_002916312.1
Coordinates 162459..162725 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO50_RS00740 (158068) 158068..159801 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
LVO50_RS00745 (159807) 159807..160520 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVO50_RS00750 (160543) 160543..161439 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVO50_RS00755 (161540) 161540..162061 + 522 WP_002916308.1 flavodoxin FldB -
LVO50_RS00760 (162068) 162068..162478 - 411 WP_002916310.1 protein YgfX Toxin
LVO50_RS00765 (162459) 162459..162725 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVO50_RS00770 (162971) 162971..163954 + 984 WP_022615657.1 tRNA-modifying protein YgfZ -
LVO50_RS00775 (164105) 164105..164764 - 660 WP_002916317.1 hemolysin III family protein -
LVO50_RS00780 (164928) 164928..165239 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LVO50_RS00785 (165288) 165288..166016 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVO50_RS00790 (166135) 166135..167568 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T228642 WP_002916310.1 NZ_CP089771:c162478-162068 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228642 NZ_CP124329:139496-139912 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228642 WP_002916312.1 NZ_CP089771:c162725-162459 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228642 NZ_CP124329:139269-139499 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References