Detailed information of TA system TA228635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4350485..4351001
• Replicon: chromosome
• Accession: NZ_CP089768
• Organism: Klebsiella pneumoniae strain HKE9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A085DK79
• Locus tag: LVO52_RS21070
• Protein ID: WP_009309309.1
• Coordinates: 4350485..4350769 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LVO52_RS21075
• Protein ID: WP_277695754.1
• Coordinates: 4350759..4351001 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVO52_RS21045 (4345902)	4345902..4346210	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
LVO52_RS21050 (4346295)	4346295..4346468	+	174	WP_002886906.1	hypothetical protein	-
LVO52_RS21055 (4346471)	4346471..4347214	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
LVO52_RS21060 (4347571)	4347571..4349709	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
LVO52_RS21065 (4350017)	4350017..4350481	+	465	WP_064839885.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LVO52_RS21070 (4350485)	4350485..4350769	-	285	WP_009309309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LVO52_RS21075 (4350759)	4350759..4351001	-	243	WP_277695754.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LVO52_RS21080 (4351079)	4351079..4352989	-	1911	WP_087829650.1	PRD domain-containing protein	-
LVO52_RS21085 (4353012)	4353012..4354166	-	1155	WP_277695755.1	lactonase family protein	-
LVO52_RS21090 (4354233)	4354233..4354973	-	741	WP_277695756.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-58)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11141.99 Da
• Isoelectric Point: 10.3787

>T228635 WP_009309309.1 NZ_CP089768:c4350769-4350485 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T228635 NZ_CP124328:c3829166-3828702 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.52 Da
• Isoelectric Point: 5.1088

>AT228635 WP_277695754.1 NZ_CP089768:c4351001-4350759 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRELLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT228635 NZ_CP124328:c3829501-3829166 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A085DK79