Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3603919..3604538 Replicon chromosome
Accession NZ_CP089768
Organism Klebsiella pneumoniae strain HKE9

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVO52_RS17490 Protein ID WP_002892050.1
Coordinates 3604320..3604538 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVO52_RS17485 Protein ID WP_002892066.1
Coordinates 3603919..3604293 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO52_RS17475 (3599071) 3599071..3600264 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVO52_RS17480 (3600287) 3600287..3603433 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVO52_RS17485 (3603919) 3603919..3604293 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVO52_RS17490 (3604320) 3604320..3604538 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVO52_RS17495 (3604697) 3604697..3605263 + 567 WP_225372328.1 maltose O-acetyltransferase -
LVO52_RS17500 (3605235) 3605235..3605375 - 141 WP_225372327.1 hypothetical protein -
LVO52_RS17505 (3605396) 3605396..3605866 + 471 WP_002892026.1 YlaC family protein -
LVO52_RS17510 (3605841) 3605841..3607292 - 1452 WP_277694938.1 PLP-dependent aminotransferase family protein -
LVO52_RS17515 (3607393) 3607393..3608091 + 699 WP_277694940.1 GNAT family protein -
LVO52_RS17520 (3608088) 3608088..3608228 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVO52_RS17525 (3608228) 3608228..3608491 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T228633 WP_002892050.1 NZ_CP089768:3604320-3604538 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T228633 NZ_CP124328:3415226-3415333 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT228633 WP_002892066.1 NZ_CP089768:3603919-3604293 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT228633 NZ_CP124328:c3415169-3415112 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References