Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 382742..383399 Replicon chromosome
Accession NZ_CP089768
Organism Klebsiella pneumoniae strain HKE9

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVO52_RS02030 Protein ID WP_002916310.1
Coordinates 382989..383399 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVO52_RS02025 Protein ID WP_002916312.1
Coordinates 382742..383008 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO52_RS02000 (377898) 377898..379331 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LVO52_RS02005 (379450) 379450..380178 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVO52_RS02010 (380228) 380228..380539 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LVO52_RS02015 (380703) 380703..381362 + 660 WP_002916317.1 hemolysin III family protein -
LVO52_RS02020 (381513) 381513..382496 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LVO52_RS02025 (382742) 382742..383008 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVO52_RS02030 (382989) 382989..383399 + 411 WP_002916310.1 protein YgfX Toxin
LVO52_RS02035 (383406) 383406..383927 - 522 WP_002916308.1 flavodoxin FldB -
LVO52_RS02040 (384028) 384028..384924 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVO52_RS02045 (384947) 384947..385660 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVO52_RS02050 (385666) 385666..387400 + 1735 Protein_398 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T228620 WP_002916310.1 NZ_CP089768:382989-383399 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T228620 NZ_CP124328:c918916-918662 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228620 WP_002916312.1 NZ_CP089768:382742-383008 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228620 NZ_CP124328:c919164-918913 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References