Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2404280..2404796 Replicon chromosome
Accession NZ_CP089765
Organism Klebsiella pneumoniae strain HKC2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LVO53_RS11750 Protein ID WP_004178374.1
Coordinates 2404512..2404796 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVO53_RS11745 Protein ID WP_002886901.1
Coordinates 2404280..2404522 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO53_RS11730 (2400308) 2400308..2401048 + 741 WP_002886899.1 KDGP aldolase family protein -
LVO53_RS11735 (2401115) 2401115..2402269 + 1155 WP_004178372.1 lactonase family protein -
LVO53_RS11740 (2402292) 2402292..2404202 + 1911 WP_004178373.1 PRD domain-containing protein -
LVO53_RS11745 (2404280) 2404280..2404522 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVO53_RS11750 (2404512) 2404512..2404796 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVO53_RS11755 (2404800) 2404800..2405264 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVO53_RS11760 (2405505) 2405505..2407643 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LVO53_RS11765 (2408000) 2408000..2408743 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVO53_RS11770 (2408746) 2408746..2408919 - 174 WP_032408826.1 hypothetical protein -
LVO53_RS11775 (2409049) 2409049..2409312 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T228606 WP_004178374.1 NZ_CP089765:2404512-2404796 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T228606 NZ_CP124326:2799747-2799854 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT228606 WP_002886901.1 NZ_CP089765:2404280-2404522 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT228606 NZ_CP124326:c2799690-2799635 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References