Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3087154..3087808 Replicon chromosome
Accession NC_010658
Organism Shigella boydii CDC 3083-94

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag SBBS512_RS18920 Protein ID WP_000244777.1
Coordinates 3087154..3087561 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SBBS512_RS18925 Protein ID WP_000354046.1
Coordinates 3087542..3087808 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBBS512_RS18900 3083111..3084844 - 1734 WP_000813182.1 single-stranded-DNA-specific exonuclease RecJ -
SBBS512_RS18905 3084850..3085560 - 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SBBS512_RS18910 3085585..3086481 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SBBS512_RS18915 3086593..3087114 + 522 WP_001055874.1 flavodoxin FldB -
SBBS512_RS18920 3087154..3087561 - 408 WP_000244777.1 toxin CptA Toxin
SBBS512_RS18925 3087542..3087808 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SBBS512_RS18930 3088051..3089031 + 981 WP_000886098.1 tRNA-modifying protein YgfZ -
SBBS512_RS18935 3089227..3089886 - 660 WP_000250274.1 hemolysin III family protein -
SBBS512_RS18940 3090050..3090361 - 312 WP_001182969.1 N(4)-acetylcytidine aminohydrolase -
SBBS512_RS18945 3090406..3091839 + 1434 WP_024258645.1 6-phospho-beta-glucosidase BglA -
SBBS512_RS18950 3091896..3092639 - 744 WP_000951947.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T22860 WP_000244777.1 NC_010658:c3087561-3087154 [Shigella boydii CDC 3083-94]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T22860 NC_010658:c3087561-3087154 [Shigella boydii CDC 3083-94]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT22860 WP_000354046.1 NC_010658:c3087808-3087542 [Shigella boydii CDC 3083-94]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT22860 NC_010658:c3087808-3087542 [Shigella boydii CDC 3083-94]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References