Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2888798..2889381 Replicon chromosome
Accession NC_010658
Organism Shigella boydii CDC 3083-94

Toxin (Protein)


Gene name mazF Uniprot ID Q31XK8
Locus tag SBBS512_RS17775 Protein ID WP_000254733.1
Coordinates 2889046..2889381 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag SBBS512_RS17770 Protein ID WP_000581937.1
Coordinates 2888798..2889046 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBBS512_RS17760 2885137..2886438 + 1302 WP_000046829.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
SBBS512_RS17765 2886486..2888720 + 2235 WP_000226851.1 GTP diphosphokinase -
SBBS512_RS17770 2888798..2889046 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SBBS512_RS17775 2889046..2889381 + 336 WP_000254733.1 endoribonuclease MazF Toxin
SBBS512_RS17780 2889452..2890243 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
SBBS512_RS17785 2890471..2892108 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
SBBS512_RS17790 2892196..2893494 + 1299 WP_000036723.1 phosphopyruvate hydratase -
SBBS512_RS17795 2893554..2894123 - 570 Protein_2916 TPM domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12167.15 Da        Isoelectric Point: 8.7218

>T22859 WP_000254733.1 NC_010658:2889046-2889381 [Shigella boydii CDC 3083-94]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKR
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T22859 NC_010658:2889046-2889381 [Shigella boydii CDC 3083-94]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT22859 WP_000581937.1 NC_010658:2888798-2889046 [Shigella boydii CDC 3083-94]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT22859 NC_010658:2888798-2889046 [Shigella boydii CDC 3083-94]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31XK8

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References