Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 41060..41714 Replicon chromosome
Accession NZ_CP089762
Organism Klebsiella pneumoniae strain HKC1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LVO51_RS00200 Protein ID WP_004144731.1
Coordinates 41307..41714 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVO51_RS00195 Protein ID WP_002916312.1
Coordinates 41060..41326 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVO51_RS00170 (LVO51_00170) 36216..37649 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LVO51_RS00175 (LVO51_00175) 37768..38496 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVO51_RS00180 (LVO51_00180) 38546..38857 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LVO51_RS00185 (LVO51_00185) 39021..39680 + 660 WP_002916317.1 hemolysin III family protein -
LVO51_RS00190 (LVO51_00190) 39831..40814 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LVO51_RS00195 (LVO51_00195) 41060..41326 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVO51_RS00200 (LVO51_00200) 41307..41714 + 408 WP_004144731.1 protein YgfX Toxin
LVO51_RS00205 (LVO51_00205) 41721..42242 - 522 WP_002916308.1 flavodoxin FldB -
LVO51_RS00210 (LVO51_00210) 42343..43239 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVO51_RS00215 (LVO51_00215) 43262..43975 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVO51_RS00220 (LVO51_00220) 43981..45713 + 1733 Protein_42 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T228578 WP_004144731.1 NZ_CP089762:41307-41714 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T228578 NZ_CP124324:2012016-2012267 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT228578 WP_002916312.1 NZ_CP089762:41060-41326 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT228578 NZ_CP124324:2012264-2012518 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References