Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 137168..137673 Replicon chromosome
Accession NZ_CP089745
Organism Pseudomonas aeruginosa strain Pa608

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LRP95_RS00625 Protein ID WP_003083773.1
Coordinates 137168..137449 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag LRP95_RS00630 Protein ID WP_003083775.1
Coordinates 137446..137673 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP95_RS00600 132419..133768 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
LRP95_RS00605 133817..134503 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
LRP95_RS00610 134604..135338 + 735 WP_003117208.1 GntR family transcriptional regulator -
LRP95_RS00615 135518..135928 + 411 WP_003101225.1 aegerolysin family protein -
LRP95_RS00620 135960..136868 - 909 WP_003083769.1 LysR family transcriptional regulator -
LRP95_RS00625 137168..137449 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LRP95_RS00630 137446..137673 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
LRP95_RS00635 137849..138469 - 621 WP_003101226.1 hypothetical protein -
LRP95_RS00640 138570..139070 + 501 WP_003112629.1 LEA type 2 family protein -
LRP95_RS00645 139143..139484 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LRP95_RS00650 139566..140993 - 1428 WP_003083784.1 GABA permease -
LRP95_RS00655 141162..142655 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T228572 WP_003083773.1 NZ_CP089745:c137449-137168 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T228572 NZ_CP124324:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT228572 WP_003083775.1 NZ_CP089745:c137673-137446 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT228572 NZ_CP124324:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References