Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3578925..3579706 Replicon chromosome
Accession NZ_CP089742
Organism Melaminivora jejuensis strain KACC 19629

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag LVC68_RS16490 Protein ID WP_209423453.1
Coordinates 3578925..3579431 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag LVC68_RS16495 Protein ID WP_209423452.1
Coordinates 3579428..3579706 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVC68_RS16470 (LVC68_16470) 3574090..3577467 - 3378 WP_209423458.1 ATP-binding protein -
LVC68_RS16475 (LVC68_16475) 3577470..3577811 - 342 WP_209423457.1 DUF86 domain-containing protein -
LVC68_RS16480 (LVC68_16480) 3577801..3578103 - 303 WP_209423456.1 nucleotidyltransferase domain-containing protein -
LVC68_RS16485 (LVC68_16485) 3578172..3578879 - 708 WP_232653842.1 DUF4194 domain-containing protein -
LVC68_RS16490 (LVC68_16490) 3578925..3579431 - 507 WP_209423453.1 GNAT family N-acetyltransferase Toxin
LVC68_RS16495 (LVC68_16495) 3579428..3579706 - 279 WP_209423452.1 DUF1778 domain-containing protein Antitoxin
LVC68_RS16500 (LVC68_16500) 3579912..3580850 - 939 WP_232653845.1 GSU2403 family nucleotidyltransferase fold protein -
LVC68_RS16505 (LVC68_16505) 3580963..3582459 - 1497 WP_209423450.1 DUF3375 domain-containing protein -
LVC68_RS16510 (LVC68_16510) 3582506..3583624 - 1119 WP_209422546.1 ISAs1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-141)

Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18834.72 Da        Isoelectric Point: 9.6559

>T228568 WP_209423453.1 NZ_CP089742:c3579431-3578925 [Melaminivora jejuensis]
MSQRYTAIRKLAASDRTEGFDCGQPALNQFLQRYALVNQKAHNAQTYVCCQQDVVVGFYSLSVGSVQPQVAPQRVMQGMA
RHPVPVMLLARLAIDLAHQRQGLGRALLRDALLRTAQAADIAGIRYLLVHAKDGAARRWYEGWEFEPSPTDSYHHLFLLL
KDFKALVA

Download         Length: 507 bp

>T228568 NZ_CP124322:4537256-4537633 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACCCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10168.53 Da        Isoelectric Point: 8.8756

>AT228568 WP_209423452.1 NZ_CP089742:c3579706-3579428 [Melaminivora jejuensis]
MNSPSLAKTERIDVRTSGPAKQLLQEAARASHKNVSEFLLDAGLTAAAQTLADRRQFLLDEAQWQAFEAALDRPVQHKPR
LQALLRESGFLG

Download         Length: 279 bp

>AT228568 NZ_CP124322:4536798-4537166 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGATACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References