Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 3080888..3081408 Replicon chromosome
Accession NZ_CP089742
Organism Melaminivora jejuensis strain KACC 19629

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LVC68_RS14340 Protein ID WP_209423804.1
Coordinates 3081124..3081408 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LVC68_RS14335 Protein ID WP_209423805.1
Coordinates 3080888..3081121 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVC68_RS14285 (LVC68_14285) 3076614..3077012 - 399 WP_209423819.1 GtrA family protein -
LVC68_RS16950 3077246..3077374 + 129 WP_267912117.1 BrnT family toxin -
LVC68_RS14290 (LVC68_14290) 3077436..3077672 + 237 WP_232654398.1 BrnA antitoxin family protein -
LVC68_RS14295 (LVC68_14295) 3077860..3078165 + 306 WP_209423816.1 helix-turn-helix transcriptional regulator -
LVC68_RS14300 (LVC68_14300) 3078131..3078526 + 396 WP_209423814.1 HipA N-terminal domain-containing protein -
LVC68_RS14305 (LVC68_14305) 3078939..3079193 + 255 WP_209423811.1 XRE family transcriptional regulator -
LVC68_RS14310 (LVC68_14310) 3079248..3079439 + 192 WP_232653698.1 type II toxin-antitoxin system RelE/ParE family toxin -
LVC68_RS14315 (LVC68_14315) 3079423..3079695 + 273 WP_209423809.1 helix-turn-helix transcriptional regulator -
LVC68_RS14320 (LVC68_14320) 3079692..3079973 + 282 WP_209423808.1 hypothetical protein -
LVC68_RS14325 (LVC68_14325) 3079960..3080280 + 321 WP_209423807.1 hypothetical protein -
LVC68_RS14330 (LVC68_14330) 3080384..3080635 + 252 WP_209423806.1 helix-turn-helix transcriptional regulator -
LVC68_RS14335 (LVC68_14335) 3080888..3081121 + 234 WP_209423805.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVC68_RS14340 (LVC68_14340) 3081124..3081408 + 285 WP_209423804.1 type II toxin-antitoxin system YafQ family toxin Toxin
LVC68_RS14345 (LVC68_14345) 3081522..3081626 + 105 Protein_2822 BrnA antitoxin family protein -
LVC68_RS14350 (LVC68_14350) 3082120..3083667 + 1548 WP_209423801.1 class I SAM-dependent methyltransferase -
LVC68_RS14355 (LVC68_14355) 3083749..3086067 - 2319 WP_209423800.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-71)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10937.48 Da        Isoelectric Point: 9.0247

>T228566 WP_209423804.1 NZ_CP089742:3081124-3081408 [Melaminivora jejuensis]
VARTLEETSQFKRDKKRIKGSGRHDWEKMRTVVTELMNDRPLAPKHRDHDLVGDYVGVRECHITPDWLLIYDKEGPLPTG
SLRLIRTGSHSELF

Download         Length: 285 bp

>T228566 NZ_CP124322:c4154712-4154425 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8161.47 Da        Isoelectric Point: 8.8347

>AT228566 WP_209423805.1 NZ_CP089742:3080888-3081121 [Melaminivora jejuensis]
MLTADVRSRVEPELKREAAAVLKASGLDLSTAIRLFLRSVVEQGGLPMELPRANADTLAAIREAKAGKTTSVSLADL

Download         Length: 234 bp

>AT228566 NZ_CP124322:c4154438-4154136 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References