Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1626276..1626762 Replicon chromosome
Accession NZ_CP089742
Organism Melaminivora jejuensis strain KACC 19629

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LVC68_RS07565 Protein ID WP_233457478.1
Coordinates 1626475..1626762 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LVC68_RS07560 Protein ID WP_232654244.1
Coordinates 1626276..1626485 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVC68_RS07545 (LVC68_07545) 1622170..1623873 + 1704 WP_233457583.1 AMP-binding protein -
LVC68_RS07550 (LVC68_07550) 1623929..1625761 + 1833 WP_232654243.1 ABC transporter transmembrane domain-containing protein -
LVC68_RS07555 (LVC68_07555) 1625808..1626167 - 360 WP_209422107.1 toxin-antitoxin system HicB family antitoxin -
LVC68_RS07560 (LVC68_07560) 1626276..1626485 + 210 WP_232654244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVC68_RS07565 (LVC68_07565) 1626475..1626762 + 288 WP_233457478.1 Txe/YoeB family addiction module toxin Toxin
LVC68_RS07570 (LVC68_07570) 1626833..1628398 + 1566 WP_232654245.1 Fic family protein -
LVC68_RS07575 (LVC68_07575) 1628588..1629178 - 591 WP_209422104.1 hypothetical protein -
LVC68_RS07580 (LVC68_07580) 1629251..1629541 - 291 WP_209422103.1 hypothetical protein -
LVC68_RS07585 (LVC68_07585) 1629578..1629721 - 144 WP_209422102.1 DUF1010 domain-containing protein -
LVC68_RS07590 (LVC68_07590) 1629718..1630275 - 558 WP_209422101.1 hypothetical protein -
LVC68_RS07595 (LVC68_07595) 1630283..1630573 - 291 WP_209422100.1 DUF1010 domain-containing protein -
LVC68_RS07600 (LVC68_07600) 1630802..1631698 - 897 WP_209422099.1 3-hydroxyisobutyrate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(15-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11214.90 Da        Isoelectric Point: 8.6815

>T228562 WP_233457478.1 NZ_CP089742:1626475-1626762 [Melaminivora jejuensis]
MPIESPADRLVRLTWTQAAWDDYAYWQGQDKKTLKRINLLIQDCLRQPLSGIGKPEPLKENLYGFWSRRIDDTNRLVYCV
DGQALVVIACRYHYR

Download         Length: 288 bp

>T228562 NZ_CP124322:c3602561-3602259 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7468.36 Da        Isoelectric Point: 4.4084

>AT228562 WP_232654244.1 NZ_CP089742:1626276-1626485 [Melaminivora jejuensis]
VAGAFEDADYTVIVRRDAPDAVVMSLDTFNSLMETVHLLKSPANATHLARSIAQLRAGQVQERDLADAD

Download         Length: 210 bp

>AT228562 NZ_CP124322:c3602223-3601882 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References